Imaging fluorophore-labelled intestinal tissue via fluorescence endoscope capsule

Beeley, J., Melino, G., Al-Rawhani, M., Turcanu, M., Stewart, F., Cochran, S. and Cumming, D. (2018) Imaging fluorophore-labelled intestinal tissue via fluorescence endoscope capsule. Proceedings, 2(13), 766. (doi: 10.3390/proceedings2130766)

Abstract

The authors have developed a wireless fluorescence imaging capsule endoscope, potentially capable of detecting early signs of disease in the human intestine which can be missed by white-light imaging (WLI) capsule endoscopy (Figure 1). Intestinal fluorescence imaging exploits variations in tissue autofluorescence between healthy and diseased areas in response to illumination, or application of fluorescent labels which preferentially bind to diseased sites. To validate the capsule’s capability to image fluorescently-labelled tissue, a small area of a sample of ex vivo porcine small intestine was sonicated with 6 nm CdZnMg fluorescent quantum dots, and the labelled area clearly differentiated from surrounding tissue by the fluorescence imaging capsule.

• Item Type: Articles
• Additional Information: The project was funded by EPSRC grant EP/K034537/1
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Al-Rawhani, Dr Mohammed and Cumming, Professor David and Turcanu, Mihnea and Beeley, Dr James and MELINO, GIANLUCA
• Authors: Beeley, J., Melino, G., Al-Rawhani, M., Turcanu, M., Stewart, F., Cochran, S., and Cumming, D.
• College/School: College of Science and Engineering; College of Science and Engineering > School of Engineering; College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
• Journal Name: Proceedings
• Publisher: MDPI
• ISSN: 2504-3900
• ISSN (Online): 2504-3900
• Copyright Holders: Copyright © 2018 The Authors
• First Published: First published in Proceedings 13:766
• Publisher Policy: Reproduced under a Creative Commons License