The genetic basis of disease

Jackson, M., Marks, L., May, G. H.W. and Wilson, J. B. (2018) The genetic basis of disease. Essays In Biochemistry, 62(5), pp. 643-723. (doi: 10.1042/EBC20170053)

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Abstract

Genetics plays a role, to a greater or lesser extent, in all diseases. Variations in our DNA and differences in how that DNA functions (alone or in combinations), alongside the environment (which encompasses lifestyle), contribute to disease processes. This review explores the genetic basis of human disease, including single gene disorders, chromosomal imbalances, epigenetics, cancer and complex disorders, and considers how our understanding and technological advances can be applied to provision of appropriate diagnosis, management and therapy for patients.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Wilson, Professor Joanna and Jackson, Dr Maria and May, Dr Gerhard and Marks, Dr Leah
Authors: Jackson, M., Marks, L., May, G. H.W., and Wilson, J. B.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
College of Medical Veterinary and Life Sciences > School of Molecular Biosciences
Journal Name:Essays In Biochemistry
Publisher:Portland Press
ISSN:0071-1365
ISSN (Online):1744-1358
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Essays In Biochemistry 62(5): 643-723
Publisher Policy:Reproduced under a Creative Commons License

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