Clinical trials for the diagnosis and management of stable ischaemic heart disease: context, status and future implications

Corcoran, D., Mangion, K. and Berry, C. (2016) Clinical trials for the diagnosis and management of stable ischaemic heart disease: context, status and future implications. European Medical Journal Cardiology, 4(1), pp. 112-121.

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Abstract

Chest pain and coronary artery disease (CAD) impose a substantial burden on public health and society. Diagnostic imaging tests are used by clinicians to identify the presence and extent of epicardial coronary disease and/or its consequences, including ischaemia, infarction, and left ventricular dysfunction. In this article, we discuss current practice guideline recommendations for the diagnosis and management of patients with suspected or known CAD, and the need for more evidence from clinical trials. We then focus on the recently published and ongoing multicentre clinical trials of imaging-based strategies for the diagnosis and management of ischaemic heart disease, and the potential future impact of these trials on clinical practice. The results of these trials have the potential to bring radical changes to the practice of cardiology in the future.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Berry, Professor Colin and Corcoran, Dr David and Mangion, Dr Kenneth
Authors: Corcoran, D., Mangion, K., and Berry, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:European Medical Journal Cardiology
Publisher:European Medical Journal
ISSN:2054-3174
ISSN (Online):2054-3174
Published Online:13 October 2016
Copyright Holders:Copyright © 2016 The Authors
First Published:First published in European Medical Journal Cardiology 4(1): 112-121
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
628691Microvascular Dysfunction in Patients with Angina: The CE-MARC2 Microvascular SubstudyColin BerryBritish Heart Foundation (BHF)FS/14/15/30661RI CARDIOVASCULAR & MEDICAL SCIENCES
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548451Clinical Evaluation of 3T Magnetic Resonance Imaging for the management of patients with Coronary heart disease: the CE-MARC2 studyColin BerryBritish Heart Foundation (BHF)SP/12/1/29062RI CARDIOVASCULAR & MEDICAL SCIENCES