Construction of a database of benzene biological monitoring

Pople, J.E., Ball, R.L., Padgett, M. and Aston, J.P. (2002) Construction of a database of benzene biological monitoring. Toxicology Letters, 134(1-3), 301 -304. (doi: 10.1016/S0378-4274(02)00194-7)

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Biological monitoring of occupational exposure to benzene has been conducted in the petroleum, steel and chemical industries. The urinary benzene-specific biomarker, S-phenylmercapturic acid (PMA), was quantified in post-shift samples using a sensitive enzyme-linked immunosorbent assay (ELISA) and expressed as a function of urinary creatinine concentration. The assay, based on a PMA-specific antiserum, is sufficiently sensitive to measure PMA levels in non-occupationally exposed control subjects. The assay delivers batch results in a timely manner which may be as short as 3 h. Samples were analysed from groups of workers engaged in coke oven combustion processes, petroleum refining and decontamination of a benzene land spill. The construction of a database of results provides an index of benzene uptake as a consequence of the respective work processes and tasks and readily enables benchmarking exercises aimed at comparing degrees of exposure across segments of industry.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Padgett, Professor Miles
Authors: Pople, J.E., Ball, R.L., Padgett, M., and Aston, J.P.
Subjects:R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine
College/School:College of Science and Engineering > School of Physics and Astronomy
Journal Name:Toxicology Letters

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