Katsoulidis, A. P., Antypov, D., Whitehead, G. F.S., Carrington, E. J., Adams, D. J. , Berry, N. G., Darling, G. R., Dyer, M. S. and Rosseinsky, M. J. (2019) Conformational control of structure and guest uptake by a tripeptide-based porous material. Nature, 565(7738), pp. 213-217. (doi: 10.1038/s41586-018-0820-9) (PMID:30626943)
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Abstract
Chemical processes often rely on the selective sorting and transformation of molecules according to their size, shape and chemical functionality. For example, porous materials such as zeolites achieve the required selectivity through the constrained pore dimensions of a single structure.1 In contrast, proteins function by navigating between multiple metastable structures using bond rotations of the polypeptide,2,3 where each structure lies in one of the minima of a conformational energy landscape and can be selected according to the chemistry of the molecules interacting with the protein.3 Here we show that rotation about covalent bonds in a peptide linker can change a flexible metal-organic framework (MOF) to afford nine distinct crystal structures, revealing a conformational energy landscape characterised by multiple structural minima. The uptake of small molecule guests by the MOF can be chemically triggered by inducing peptide conformational change. This change transforms the material from a minimum on the landscape that is inactive for guest sorption to an active one. Chemical control of the conformation of a flexible organic linker offers a route to modify the pore geometry and internal surface chemistry and thus the function of open-framework materials.
Item Type: | Articles |
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Additional Information: | This project has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (grant agreement n° 692685) and from the Engineering and Physical Sciences Research Council (EP/J008834). We acknowledge the HPC Materials Chemistry Consortium for providing access to UK's national supercomputer ARCHER under the EPSRC grant EP/L000202. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Adams, Dave |
Authors: | Katsoulidis, A. P., Antypov, D., Whitehead, G. F.S., Carrington, E. J., Adams, D. J., Berry, N. G., Darling, G. R., Dyer, M. S., and Rosseinsky, M. J. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Nature |
Publisher: | Nature Research |
ISSN: | 0028-0836 |
ISSN (Online): | 1476-4687 |
Published Online: | 09 January 2019 |
Copyright Holders: | Copyright © 2019 Springer Nature Limited |
First Published: | First published in Nature 565(7738): 213-217 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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