Differential regulation of the variations induced by environmental richness in adult neurogenesis as a function of time: A dual birthdating analysis

Tsien, J. Z., Llorens-Martín, M., Tejeda, G. S. and Trejo, J. L. (2010) Differential regulation of the variations induced by environmental richness in adult neurogenesis as a function of time: A dual birthdating analysis. PLoS ONE, 5(8), e12188. (doi: 10.1371/journal.pone.0012188) (PMID:20808440) (PMCID:PMC2922333)

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Abstract

Adult hippocampal neurogenesis (AHN) augments after environmental enrichment (EE) and it has been related to some of the anxiolytic, antidepressant and neuroprotective effects of EE. Indeed, it has been suggested that EE specifically modulates hippocampal neurogenic cell populations over the course of time. Here we have used dual-birthdating to study two subpopulations of newborn neuron in mice (Mus musculus): those born at the beginning and at the end of enrichment. In this way, we demonstrate that while short-term cell survival is upregulated after an initial 1 week period of enrichment in 2 month old female mice, after long-term enrichment (2 months) neither cell proliferation nor the survival of the younger newly born cell populations are distinguishable from that observed in non-enriched control mice. In addition, we show that the survival of older newborn neurons alone (i.e. those born at the beginning of the enrichment) is higher than in controls, due to the significantly lower levels of cell death. Indeed, these parameters are rapidly adjusted to the sudden cessation of the EE conditions. These findings suggest both an early selective, long-lasting effect of EE on the neurons born in the initial stages of enrichment, and a quick response when the environment again becomes impoverished. Therefore, EE induces differential effects on distinct subpopulations of newborn neurons depending on the age of the immature cells and on the duration of the EE itself. The interaction of these two parameters constitutes a new, specific regulation of these neurogenic populations that might account for the long-term enrichment's behavioral effects.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Tejeda, Dr Gonzalo
Authors: Tsien, J. Z., Llorens-Martín, M., Tejeda, G. S., and Trejo, J. L.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:PLoS ONE
Publisher:Public Library of Science
ISSN:1932-6203
ISSN (Online):1932-6203
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in PLoS ONE 5(8):e12188
Publisher Policy:Reproduced under a Creative Commons License

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