Control freaks-signals and cues governing the regulation of virulence in attaching and effacing pathogens

Turner, N. C.A., Connolly, J. P.R. and Roe, A. (2019) Control freaks-signals and cues governing the regulation of virulence in attaching and effacing pathogens. Biochemical Society Transactions, 47(1), pp. 229-238. (doi: 10.1042/BST20180546) (PMID:30559275) (PMCID:PMC6393859)

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Abstract

Enterohaemorrhagic Escherichia coli (EHEC) mediates disease using a type 3 secretion system (T3SS), which is encoded on the locus of enterocyte effacement (LEE) and is tightly controlled by master regulators. This system is further modulated by a number of signals that help to fine-tune virulence, including metabolic, environmental and chemical signals. Since the LEE, and its master regulator, Ler, were established there have been numerous scientific advancements in understanding the regulation and expression of virulence factors in EHEC. This review will discuss the recent advancements in this field since our previous review, with a focus on transcriptional regulation of the LEE.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Turner, Natasha and Connolly, Dr James and Roe, Professor Andrew
Authors: Turner, N. C.A., Connolly, J. P.R., and Roe, A.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Biochemical Society Transactions
Publisher:Portland Press
ISSN:0300-5127
ISSN (Online):1470-8752
Published Online:17 December 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Biochemical Society Transactions 47(1): 229-238
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
3002800The Role of Dietary D-serine in Health and DiseaseAndrew RoeBiotechnology and Biological Sciences Research Council (BBSRC)BB/R006539/1III - Bacteriology
691101Where and Why: The Influence of Host Metabolism on Bacterial Niche SpecificityAndrew RoeBiotechnology and Biological Sciences Research Council (BBSRC)BB/M029646/1III - BACTERIOLOGY