Inflammatory cytokines in juvenile idiopathic arthritis: Effects on physical growth and the insulin-like-growth factor axis

Wong, S.C., Macrae, V.E., Gracie, J.A., McInnes, I.B. , Galea, P., Gardner-Medwin, J. and Ahmed, S.F. (2008) Inflammatory cytokines in juvenile idiopathic arthritis: Effects on physical growth and the insulin-like-growth factor axis. Growth Hormone and IGF Research, 18(5), pp. 369-378. (doi:10.1016/j.ghir.2008.01.006) (PMID:18378173)

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Abstract

Objective: To investigate the relationship between markers of inflammation with physical growth and systemic markers of GH secretion in JIA. Design: This is a cross sectional prospective study of patients with JIA recruited during therapeutic arthrocentesis of 17 children with JIA (F, 10): 8 oligoarticular (OJIA) and 9 polyarticular (PJIA). Results: Median adjusted height (AHt) SDS was −0.3 (−2.2 to 1.6). Serum ALS SDS (median −1.3, range −2.7 to −0.6) was reduced compared with serum IGFBP-3 SDS (median −0.5, range −7.7 to 2.3) and IGF-1 SDS (median −0.2, range −0.5 to 0.5). Log serum IL5 (95% CI −3.25, −0.81) and log serum IL15 (95% CI −9.58, −4.10) were independent factors associated with AHt SDS. Inflammatory cytokines individually showed no association with IGF-1, IGFBP-1, -2, -3 and ALS. Conclusion: Children with JIA and mild degree of growth retardation show decreased ALS and IGFBP-3. Cytokines did not show an association to systemic markers of GH secretion. However, this study reports the novel, preliminary association between serum levels of IL5 and IL15 and the extent of short stature.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McInnes, Professor Iain and Gardner-Medwin, Dr Janet and Ahmed, Professor Syed Faisal and Wong, Dr Jarod and Gracie, Professor J Alastair
Authors: Wong, S.C., Macrae, V.E., Gracie, J.A., McInnes, I.B., Galea, P., Gardner-Medwin, J., and Ahmed, S.F.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
Journal Name:Growth Hormone and IGF Research
Journal Abbr.:Growth Horm. IGF Res.
Publisher:Elsevier
ISSN:1096-6374
ISSN (Online):1532-2238
Published Online:02 April 2008

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