The antiviral piRNA response in mosquitoes?

Varjak, M. , Leggewie, M. and Schnettler, E. (2018) The antiviral piRNA response in mosquitoes? Journal of General Virology, 99(12), pp. 1551-1562. (doi:10.1099/jgv.0.001157) (PMID:30372405)

[img]
Preview
Text
172502.pdf - Published Version
Available under License Creative Commons Attribution.

703kB

Abstract

There are several RNA interference (RNAi) pathways in insects. The small interfering RNA pathway is considered to be the main antiviral mechanism of the innate immune system; however, virus-specific P-element-induced Wimpy testis gene (PIWI)-interacting RNAs (vpiRNAs) have also been described, especially in mosquitoes. Understanding the antiviral potential of the RNAi pathways is important, given that many human and animal pathogens are transmitted by mosquitoes, such as Zika virus, dengue virus and chikungunya virus. In recent years, significant progress has been made to characterize the piRNA pathway in mosquitoes (including the possible antiviral activity) and to determine the differences between mosquitoes and the model organism Drosophila melanogaster. The new findings, especially regarding vpiRNA in mosquitoes, as well as important questions that need to be tackled in the future, are discussed in this review.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Schnettler, Dr Esther and Varjak, Dr Margus
Authors: Varjak, M., Leggewie, M., and Schnettler, E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of General Virology
Publisher:Society for General Microbiology
ISSN:0022-1317
ISSN (Online):1465-2099
Published Online:29 October 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Journal of General Virology 99(12): 1551-1562
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
737371ZikallianceAlain KohlEuropean Commission (EC)734548MVLS III - CENTRE FOR VIRUS RESEARCH
656551Arbovirus interactions with arthropod hostsAlain KohlMedical Research Council (MRC)MC_UU_12014/8MVLS III - CENTRE FOR VIRUS RESEARCH

Downloads per month over past year

View more statistics