The antiviral piRNA response in mosquitoes?

Varjak, M. , Leggewie, M. and Schnettler, E. (2018) The antiviral piRNA response in mosquitoes? Journal of General Virology, 99(12), pp. 1551-1562. (doi: 10.1099/jgv.0.001157) (PMID:30372405)

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There are several RNA interference (RNAi) pathways in insects. The small interfering RNA pathway is considered to be the main antiviral mechanism of the innate immune system; however, virus-specific P-element-induced Wimpy testis gene (PIWI)-interacting RNAs (vpiRNAs) have also been described, especially in mosquitoes. Understanding the antiviral potential of the RNAi pathways is important, given that many human and animal pathogens are transmitted by mosquitoes, such as Zika virus, dengue virus and chikungunya virus. In recent years, significant progress has been made to characterize the piRNA pathway in mosquitoes (including the possible antiviral activity) and to determine the differences between mosquitoes and the model organism Drosophila melanogaster. The new findings, especially regarding vpiRNA in mosquitoes, as well as important questions that need to be tackled in the future, are discussed in this review.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Schnettler, Dr Esther and Varjak, Dr Margus
Authors: Varjak, M., Leggewie, M., and Schnettler, E.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Journal of General Virology
Publisher:Society for General Microbiology
ISSN (Online):1465-2099
Published Online:29 October 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Journal of General Virology 99(12): 1551-1562
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
737371ZikallianceAlain KohlEuropean Commission (EC)734548MVLS III - CENTRE FOR VIRUS RESEARCH
656551Arbovirus interactions with arthropod hostsAlain KohlMedical Research Council (MRC)MC_UU_12014/8MVLS III - CENTRE FOR VIRUS RESEARCH