A novel cellular pathway of antigen presentation and CD4 T cell activation in vivo

Scales, H. E. et al. (2018) A novel cellular pathway of antigen presentation and CD4 T cell activation in vivo. Frontiers in Immunology, 9, 2684. (doi: 10.3389/fimmu.2018.02684)

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Dendritic cell activation of CD4 T cells in the lymph node draining a site of infection or vaccination is widely considered the central event in initiating adaptive immunity. The accepted dogma is that this occurs by stimulating local activation and antigen acquisition by dendritic cells, with subsequent lymph node migration, however the generalizability of this mechanism is unclear. Here we show that in some circumstances antigen can bypass the injection site inflammatory response, draining freely and rapidly to the lymph nodes where it interacts with subcapsular sinus (SCS) macrophages resulting in their death. Debris from these dying SCS macrophages is internalized by monocytes recruited from the circulation. This coordinated response leads to antigen presentation by monocytes and interactions with naïve CD4 T cells that can drive the initiation of T cell and B cell responses. These studies demonstrate an entirely novel pathway leading to initiation of adaptive immune responses in vivo.

Item Type:Articles
Additional Information:This work was funded by CSL Limited.
Glasgow Author(s) Enlighten ID:Brewer, Professor James and Garside, Professor Paul and Benson, Dr Robert and Meehan, Dr Gavin and Hayes, Mr Alan and Scales, Dr Hannah
Authors: Scales, H. E., Meehan, G. R., Hayes, A. J., Benson, R. A., Watson, E., Walters, A., Tomura, M., Maraskovsky, E., Garside, P., Baz Morelli, A., and Brewer, J. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Frontiers in Immunology
Publisher:Frontiers Media
ISSN (Online):1664-3224
Copyright Holders:Copyright © 2018 Scales, Meehan, Hayes, Benson, Watson, Walters, Tomura, Maraskovsky, Garside, Baz Morelli and Brewer
First Published:First published in Frontiers in Immunology 9: 2684
Publisher Policy:Reproduced under a Creative Commons License

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