Application of zirconium MOFs in drug delivery and biomedicine

Abánades Lázaro, I. and Forgan, R. S. (2019) Application of zirconium MOFs in drug delivery and biomedicine. Coordination Chemistry Reviews, 380, pp. 230-259. (doi:10.1016/j.ccr.2018.09.009)

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Abstract

Nanoparticulate metal-organic frameworks (MOFs) have the requisite high storage capacities, tailorable structures, ease of functionalisation, and excellent biocompatibilities for application as nanoscale drug delivery devices (DDSs). Zirconium MOFs in particular combine optimal stability towards hydrolysis and postsynthetic modification with low toxicity, and so are particularly suited for biological applications. This review covers the use of Zr MOFs as DDSs with focus on the different physical properties that makes them attractive for use. The various methods for modifying the surfaces of Zr MOFs are described with pertinent examples of the resulting enhancements in aqueous stability, colloidal dispersion, and stimuli-responsive drug release. The in vitro and in vivo application of Zr MOFs for photodynamic therapy and drug delivery are discussed with respect to the structural features of the MOFs and their surface functionality, and perspectives on their future applications and analogous hafnium MOFs are given.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Abanades, Isabel and Forgan, Dr Ross
Authors: Abánades Lázaro, I., and Forgan, R. S.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Coordination Chemistry Reviews
Publisher:Elsevier
ISSN:0010-8545
ISSN (Online):1873-3840
Published Online:26 October 2018
Copyright Holders:Copyright © 2018 Elsevier B.V.
First Published:First published in Coordination Chemistry Reviews 380: 230-259
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
689571SCoTMOFRoss ForganEuropean Research Council (ERC)677289SCHOOL OF CHEMISTRY