Abánades Lázaro, I. and Forgan, R. S. (2019) Application of zirconium MOFs in drug delivery and biomedicine. Coordination Chemistry Reviews, 380, pp. 230-259. (doi: 10.1016/j.ccr.2018.09.009)
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Abstract
Nanoparticulate metal-organic frameworks (MOFs) have the requisite high storage capacities, tailorable structures, ease of functionalisation, and excellent biocompatibilities for application as nanoscale drug delivery devices (DDSs). Zirconium MOFs in particular combine optimal stability towards hydrolysis and postsynthetic modification with low toxicity, and so are particularly suited for biological applications. This review covers the use of Zr MOFs as DDSs with focus on the different physical properties that makes them attractive for use. The various methods for modifying the surfaces of Zr MOFs are described with pertinent examples of the resulting enhancements in aqueous stability, colloidal dispersion, and stimuli-responsive drug release. The in vitro and in vivo application of Zr MOFs for photodynamic therapy and drug delivery are discussed with respect to the structural features of the MOFs and their surface functionality, and perspectives on their future applications and analogous hafnium MOFs are given.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Abanades, Isabel and Forgan, Professor Ross |
Authors: | Abánades Lázaro, I., and Forgan, R. S. |
College/School: | College of Science and Engineering > School of Chemistry |
Journal Name: | Coordination Chemistry Reviews |
Publisher: | Elsevier |
ISSN: | 0010-8545 |
ISSN (Online): | 1873-3840 |
Published Online: | 26 October 2018 |
Copyright Holders: | Copyright © 2018 Elsevier B.V. |
First Published: | First published in Coordination Chemistry Reviews 380: 230-259 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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