Chemokine transport dynamics and emerging recognition of their role in immune function

Moore, J. E., Brook, B. S. and Nibbs, R. J.B. (2018) Chemokine transport dynamics and emerging recognition of their role in immune function. Current Opinion in Biomedical Engineering, 5, pp. 90-95. 30320240. (doi: 10.1016/j.cobme.2018.03.001) (PMID:PMC6176735)

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Abstract

Leukocyte migration is critically important during all protective and pathological immune and inflammatory responses. Chemokines play fundamental roles in this process, and chemokine concentration gradients stimulate the directional migration of leukocytes. The formation and regulation of these gradients is poorly understood. These are complex processes that depend on the specific properties of each chemokine and interactions between physical, biological and biochemical processes, including production, diffusion, advection, scavenging, post-translational modification, and extracellular matrix (ECM) binding. While some of these mechanisms have been investigated in isolation or limited combinations, more integrative research is required to provide a quantitative knowledge base that explains how chemokine gradients are established and maintained, and how cells respond to, and modify, these gradients.

Item Type:Articles
Additional Information:This work was supported by the Royal Society (WM120065), the Royal Academy of Engineering (10145/90), the Sir Leon Bagrit Trust, National Institutes of Health Grant U01-HL-123420, and Wellcome Trust Collaborative Award 206284/Z/17/Z. The U.K. Medical Research Council funds (N023625/1 and M019764/1) work in R.J.B.N.’s laboratory
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Nibbs, Professor Rob
Authors: Moore, J. E., Brook, B. S., and Nibbs, R. J.B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Current Opinion in Biomedical Engineering
Publisher:Elsevier
ISSN:2468-4511
ISSN (Online):2468-4511
Published Online:20 March 2018
Copyright Holders:Copyright © 2018 Elsevier
First Published:First published in Current Opinion in Biomedical Engineering 5:90-95
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
3014990Integrative Transport Phenomena in Chemokine Gradient EstablishmentRobert NibbsWellcome Trust (WELLCOTR)206284/Z/17/ZIII - Immunology
715631Defining mechanisms that control T cell migrationSimon MillingMedical Research Council (MRC)MR/N023625/1III -IMMUNOLOGY
681091The ACKR2-CCR2 axis in development and diseaseGerard GrahamMedical Research Council (MRC)MR/M019764/1III -IMMUNOLOGY