Array-based “chemical nose” sensing in diagnostics and drug discovery

Geng, Y., Peveler, W. J. and Rotello, V. (2019) Array-based “chemical nose” sensing in diagnostics and drug discovery. Angewandte Chemie (International Edition), 58(16), pp. 5190-5200. (doi: 10.1002/anie.201809607) (PMID:30347522)

Abstract

Array‐based sensor ‘chemical nose/tongue’ platforms are inspired by the mammalian olfactory system. Multiple sensor elements in these devices selectively interact with target analytes, producing a distinct pattern of response and enabling analyte identification. This approach offers unique opportunities relative to ‘traditional’ highly specific sensor elements such as antibodies. Array‐based sensors excel at distinguishing small changes in complex mixtures, and this capability is being leveraged for chemical biology studies and clinical pathology, enabled by a diverse toolkit of new molecular, bioconjugate and nanomaterial technologies. Innovation in the design and analysis of arrays provides a robust set of tools for advancing biomedical goals, including precision medicine.

• Item Type: Articles
• Additional Information: V.M.R. acknowledges support from the NIH (GM077173, CA207932 and AI AI134770) Y.G. receives funding from Chemistry Biology Interface program (GM008515) at University of Massachusstat Amhertst. W.J.P acknowledges the Royal Society for an International Exchange Grant, the University of Glasgow for an LKAS Fellowship and the Killam Foundation for a Postdoctoral Research Fellowship.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Peveler, Dr William
• Authors: Geng, Y., Peveler, W. J., and Rotello, V.
• College/School: College of Science and Engineering > School of Engineering > Biomedical Engineering
• Journal Name: Angewandte Chemie (International Edition)
• Publisher: Wiley
• ISSN: 1433-7851
• ISSN (Online): 1521-3773
• Published Online: 22 October 2018
• Copyright Holders: Copyright © 2018 Wiley-VCH Verlag GmbH and Co. KGaA
• First Published: First published in Angewandte Chemie (International Edition) 58(16):5190-5200
• Publisher Policy: Reproduced in accordance with the publisher copyright policy