Two mixed breed dogs with sensory neuropathy are homozygous for an inversion disrupting FAM134B previously identified in Border Collies

Amengual-Batle, P., Rusbridge, C., José-López, R., Golini, L., Shelton, G. D., Mellersh, C. S. and Gutierrez-Quintana, R. (2018) Two mixed breed dogs with sensory neuropathy are homozygous for an inversion disrupting FAM134B previously identified in Border Collies. Journal of Veterinary Internal Medicine, 32(6), pp. 2082-2087. (doi:10.1111/jvim.15312) (PMID:30307654) (PMCID:PMC6272042)

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Abstract

Two unrelated 8-month-old male mixed breed dogs were presented for evaluation of progressive ataxia, knuckling, and lack of pain perception in the distal limbs. Because of the similarity in age of onset, progression, and clinical findings with previously described sensory neuropathy in Border Collies, the affected dogs were screened for an FAM134B mutation and were determined to be homozygous for the mutation. Despite few phenotypic similarities with other breeds, genetic testing for specific diseases should be considered in mixed breed dogs with compatible clinical signs, especially if ancestry is unknown.

Item Type:Articles
Keywords:Dog, hereditary neuropathy, mutation, sensory-autonomic neuropathy.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Jose-Lopez, Mr Roberto and Gutierrez Quintana, Mr Rodrigo and Amengual Batle, Pablo
Authors: Amengual-Batle, P., Rusbridge, C., José-López, R., Golini, L., Shelton, G. D., Mellersh, C. S., and Gutierrez-Quintana, R.
College/School:College of Medical Veterinary and Life Sciences > School of Veterinary Medicine
Journal Name:Journal of Veterinary Internal Medicine
Publisher:Wiley
ISSN:0891-6640
ISSN (Online):1939-1676
Published Online:11 October 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Journal of Veterinary Internal Medicine 32(6):2082-2087
Publisher Policy:Reproduced under a Creative Commons License

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