Basripuzi, N. H., Salisi, M. S., Isa, N. M. M., Busin, V. , Cairns, C., Jenvey, C. and Stear, M. J. (2018) Boer goats appear to lack a functional IgA and eosinophil response against natural nematode infection. Veterinary Parasitology, 264, pp. 18-25. (doi: 10.1016/j.vetpar.2018.10.014) (PMID:30503086)
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Abstract
Gastrointestinal nematode infection is one of the major diseases affecting small ruminants. Although some breeds of goats are quite resistant, many breeds of goats are relatively susceptible. This study used a combined parasitological, immunological, bioinformatic and statistical approach to examine the role of goat IgA and eosinophils in protection against Teladorsagia circumcincta. Molecular modelling suggested that the transmembrane domain of the high affinity IgA receptor was dysfunctional in goats. Statistical analyses failed to find any association in naturally infected goats between high IgA or eosinophil responses and low faecal egg counts. Together these results indicate that IgA and eosinophil responses against T. circumcincta are less effective in goats than sheep.
Item Type: | Articles |
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Additional Information: | This study was supported by the Ministry of Higher Education Malaysia and Universiti Malaysia Kelantan in the forms of scholarship, bench fees and emoluments. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Salisi, Dr Mohd Shahrom and Busin, Valentina and Stear, Professor Mike |
Authors: | Basripuzi, N. H., Salisi, M. S., Isa, N. M. M., Busin, V., Cairns, C., Jenvey, C., and Stear, M. J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
Journal Name: | Veterinary Parasitology |
Publisher: | Elsevier |
ISSN: | 0304-4017 |
ISSN (Online): | 1873-2550 |
Published Online: | 22 October 2018 |
Copyright Holders: | Copyright © 2018 Elsevier B.V. |
First Published: | First published in Veterinary Parasitology 264: 18-25 |
Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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