Genetic susceptibility loci for cardiovascular disease and their impact on atherosclerotic plaques

van der Laan, S. W. et al. (2018) Genetic susceptibility loci for cardiovascular disease and their impact on atherosclerotic plaques. Circulation: Genomic and Precision Medicine, 11(9), e002115. (doi: 10.1161/CIRCGEN.118.002115)

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Background: Atherosclerosis is a chronic inflammatory disease in part caused by lipid uptake in the vascular wall, but the exact underlying mechanisms leading to acute myocardial infarction and stroke remain poorly understood. Large consortia identified genetic susceptibility loci that associate with large artery ischemic stroke and coronary artery disease. However, deciphering their underlying mechanisms are challenging. Histological studies identified destabilizing characteristics in human atherosclerotic plaques that associate with clinical outcome. To what extent established susceptibility loci for large artery ischemic stroke and coronary artery disease relate to plaque characteristics is thus far unknown but may point to novel mechanisms. Methods: We studied the associations of 61 established cardiovascular risk loci with 7 histological plaque characteristics assessed in 1443 carotid plaque specimens from the Athero-Express Biobank Study. We also assessed if the genotyped cardiovascular risk loci impact the tissue-specific gene expression in 2 independent biobanks, Biobank of Karolinska Endarterectomy and Stockholm Atherosclerosis Gene Expression. Results: A total of 21 established risk variants (out of 61) nominally associated to a plaque characteristic. One variant (rs12539895, risk allele A) at 7q22 associated to a reduction of intraplaque fat, P=5.09×10−6 after correction for multiple testing. We further characterized this 7q22 Locus and show tissue-specific effects of rs12539895 on HBP1 expression in plaques and COG5 expression in whole blood and provide data from public resources showing an association with decreased LDL (low-density lipoprotein) and increase HDL (high-density lipoprotein) in the blood. Conclusions: Our study supports the view that cardiovascular susceptibility loci may exert their effect by influencing the atherosclerotic plaque characteristics.

Item Type:Articles
Additional Information:Ian Ford, Naveed Sattar and David J. Stott are members of METASTROKE Collaboration of the International Stroke Genetics Consortium.
Glasgow Author(s) Enlighten ID:Stott J, Professor David and Ford, Professor Ian and Sattar, Professor Naveed
Authors: van der Laan, S. W., Siemelink, M. A., Haitjema, S., Foroughi Asl, H., Perisic, L., Mokry, M., van Setten, J., Malik, R., Dichgans, M., Worrall, B. B., Samani, N. J., Schunkert, H., Erdmann, J., Hedin, U., Paulsson-Berne, G., Björkegrenn, J. L.M., de Borst, G. J., Asselbergs, F. W., den Ruijter, F. W., de Bakker, P. I.W., Pasterkamp, G., Ford, I., Sattar, N., and Stott, D. J.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre
College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Circulation: Genomic and Precision Medicine
Publisher:American Heart Association
ISSN (Online):2574-8300
Published Online:17 September 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Circulation: Genomic and Precision Medicine 11(9): e002115
Publisher Policy:Reproduced under a Creative Commons License

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