Keeble, T. R. et al. (2019) Percutaneous haemodynamic and renal support in patients presenting with decompensated heart failure: A multi-centre efficacy study using the Reitan Catheter Pump (RCP). International Journal of Cardiology, 275, pp. 53-58. (doi: 10.1016/j.ijcard.2018.09.085) (PMID:30342873)
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Abstract
Background: Worsening heart failure complicated by congestion, hypotension, and renal dysfunction is difficult to manage, increasingly common and predicts a poor outcome. Novel therapies are required to facilitate diuresis and implementation of disease-modifying interventions in preparation for hospital discharge. Accordingly, we investigated the haemodynamic and renal effects of the Reitan Catheter Pump (RCP) percutaneous support device in patients admitted with decompensated heart failure (DHF). Methods: This was a prospective observational study of 20 patients admitted with DHF, ejection fraction < 30%, and Cardiac index (CI) < 2.1 L/min/m2 in need of inotropic/mechanical support. Results: Patients underwent RCP support for a mean of 18.3 (±6.3) hours. The RCP increased CI from 1.84 L/min/m2 (±0.27), to 2.41 L/min/m2 (±0.45, p = 0.04), increased urine output (71 mL/h (±65) to 227 ml/h (±179) (p = 0.006) with a concomitant reduction in serum creatinine (188 μmol/L (±87) to 161 μmol/L (±78) (p = 0.0007). There were no clinically significant haemolysis, vascular injury, or thrombo-embolic complications. Conclusions: For patients admitted with DHF, the RCP improves cardiac index, diuresis and renal function without causing important complications.
| Item Type: | Articles |
|---|---|
| Additional Information: | The trial was funded by Cardiobridge GmbH, Hechingen, Germany. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Cleland, Professor John |
| Authors: | Keeble, T. R., Karamasis, G. V., Rothman, M. T., Ricksten, S.-E., Ferrari, M., Hullin, R., Scherstén, F., Reitan, O., Kirking, S. T., Cleland, J. G.F., and Smith, E. J. |
| Subjects: | R Medicine > R Medicine (General) |
| College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre |
| Journal Name: | International Journal of Cardiology |
| Publisher: | Elsevier |
| ISSN: | 0167-5273 |
| ISSN (Online): | 1874-1754 |
| Published Online: | 01 October 2018 |
| Copyright Holders: | Copyright © 2018 Elsevier B.V. |
| First Published: | First published in International Journal of Cardiology 275: 53-58 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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