GPCR homo-oligomerization

Milligan, G. , Ward, R. J. and Marsango, S. (2019) GPCR homo-oligomerization. Current Opinion in Cell Biology, 57, pp. 40-47. (doi: 10.1016/j.ceb.2018.10.007) (PMID:30453145) (PMCID:PMC7083226)

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Abstract

G protein-coupled receptors (GPCRs) are an extensive class of trans-plasma membrane proteins that function to regulate a wide range of physiological functions. Despite a general perception that GPCRs exist as monomers an extensive literature has examined whether GPCRs can also form dimers and even higher-order oligomers, and if such organization influences various aspects of GPCR function, including cellular trafficking, ligand binding, G protein coupling and signalling. Here we focus on recent studies that employ approaches ranging from computational methods to single molecule tracking and both quantal brightness and fluorescence fluctuation measurements to assess the organization, stability and potential functional significance of dimers and oligomers within the class A, rhodopsin-like GPCR family.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ward, Dr Richard and Milligan, Professor Graeme and Marsango, Dr Sara
Authors: Milligan, G., Ward, R. J., and Marsango, S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Current Opinion in Cell Biology
Publisher:Elsevier
ISSN:0955-0674
ISSN (Online):0955-0674
Published Online:16 November 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Current Opinion in Cell Biology 57: 40-47
Publisher Policy:Reproduced under a Creative Commons License

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