Tissue engineering the cancer microenvironment—challenges and opportunities

Papalazarou, V., Salmeron-Sanchez, M. and Machesky, L. M. (2018) Tissue engineering the cancer microenvironment—challenges and opportunities. Biophysical Reviews, 10(6), pp. 1695-1711. (doi:10.1007/s12551-018-0466-8) (PMID:30406572) (PMCID:PMC6297082)

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Abstract

Mechanosensing is increasingly recognised as important for tumour progression. Tumours become stiff and the forces that normally balance in the healthy organism break down and become imbalanced, leading to increases in migration, invasion and metastatic dissemination. Here, we review recent advances in our understanding of how extracellular matrix properties, such as stiffness, viscoelasticity and architecture control cell behaviour. In addition, we discuss how the tumour microenvironment can be modelled in vitro, capturing these mechanical aspects, to better understand and develop therapies against tumour spread. We argue that by gaining a better understanding of the microenvironment and the mechanical forces that govern tumour dynamics, we can make advances in combatting cancer dormancy, recurrence and metastasis.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Salmeron-Sanchez, Professor Manuel and Machesky, Professor Laura and Papalazarou, Mr Vasileios
Authors: Papalazarou, V., Salmeron-Sanchez, M., and Machesky, L. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Science and Engineering > School of Engineering
College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Biophysical Reviews
Publisher:Springer
ISSN:1867-2450
ISSN (Online):1867-2469
Published Online:08 November 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Biophysical Reviews 10(6):1695-1711
Publisher Policy:Reproduced under a Creative Commons License

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