Small vessel disease is associated with altered cerebrovascular pulsatility but not resting cerebral blood flow

Shi, Y., Thrippleton, M. J., Blair, G. W., Dickie, D. A. , Marshall, I., Hamilton, I., Doubal, F. N., Chappell, F. and Wardlaw, J. M. (2020) Small vessel disease is associated with altered cerebrovascular pulsatility but not resting cerebral blood flow. Journal of Cerebral Blood Flow and Metabolism, 40(1), pp. 85-99. (doi: 10.1177/0271678X18803956) (PMID:30295558)

Abstract

Cerebral small vessel disease (SVD) contributes to 25% of ischemic strokes and 45% of dementias. We aimed to investigate the role of cerebral blood flow (CBF) and intracranial pulsatility in SVD. We scanned 60 patients with minor ischemic stroke, representing a range of white matter hyperintensities (WMH). We rated WMH and perivascular spaces (PVS) using semi-quantitative scales and measured WMH volume. We measured flow and pulsatility in the main cerebral vessels and cerebrospinal fluid (CSF) using phase-contrast MRI. We investigated the association between flow, pulsatility and SVD features. In 56/60 patients (40 male, 67.8±8.3 years) with complete data, median WMH volume was 10.7 mL (range 1.4-75.0 mL), representing median 0.77% (0.11-5.17%) of intracranial volume. Greater pulsatility index (PI) in venous sinuses was associated with larger WMH volume (e.g. superior sagittal sinus, β = 1.29, P < 0.01) and more basal ganglia PVS (e.g. odds ratio = 1.38, 95% confidence interval 1.06, 1.79, per 0.1 increase in superior sagittal sinus PI) independently of age, sex and blood pressure. CSF pulsatility and CBF were not associated with SVD features. Our results support a close association of SVD features with increased intracranial pulsatility rather than with low global CBF, and provide potential targets for mechanistic research, treatment and prevention of SVD.

• Item Type: Articles
• Keywords: Cerebral blood flow, cerebral small vessel disease, cerebrovascular pulsatility, magnetic resonance imaging, perivascular spaces, stroke, white matter hyperintensities.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Dickie, Dr David Alexander
• Authors: Shi, Y., Thrippleton, M. J., Blair, G. W., Dickie, D. A., Marshall, I., Hamilton, I., Doubal, F. N., Chappell, F., and Wardlaw, J. M.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Journal of Cerebral Blood Flow and Metabolism
• Publisher: SAGE Publications
• ISSN: 0271-678X
• ISSN (Online): 1559-7016
• Published Online: 08 October 2018
• Copyright Holders: Copyright © 2018 The Authors
• First Published: First published in Journal of Cerebral Blood Flow and Metabolism 40(1): 85-99
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher