An incremental deformation model of arterial dissection

Li, B., Roper, S. M. , Wang, L., Luo, X. and Hill, N.A. (2019) An incremental deformation model of arterial dissection. Journal of Mathematical Biology, 78(5), pp. 1277-1298. (doi:10.1007/s00285-018-1309-8) (PMID:30456652) (PMCID:PMC6453878)

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Abstract

We develop a mathematical model for a small axisymmetric tear in a residually stressed and axially pre-stretched cylindrical tube. The residual stress is modelled by an opening angle when the load-free tube is sliced along a generator. This has application to the study of an aortic dissection, in which a tear develops in the wall of the artery. The artery is idealised as a single-layer thick-walled axisymmetric hyperelastic tube with collagen fibres using a Holzapfel–Gasser–Ogden strain-energy function, and the tear is treated as an incremental deformation of this tube. The lumen of the cylinder and the interior of the dissection are subject to the same constant (blood) pressure. The equilibrium equations for the incremental deformation are derived from the strain energy function. We develop numerical methods to study the opening of the tear for a range of material parameters and boundary conditions. We find that decreasing the fibre angle, decreasing the axial pre-stretch and increasing the opening angle all tend to widen the dissection, as does an incremental increase in lumen and dissection pressure.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Luo, Professor Xiaoyu and Hill, Professor Nicholas and Roper, Dr Steven
Authors: Li, B., Roper, S. M., Wang, L., Luo, X., and Hill, N.A.
College/School:College of Science and Engineering > School of Mathematics and Statistics > Mathematics
Journal Name:Journal of Mathematical Biology
Publisher:Springer
ISSN:0303-6812
ISSN (Online):1432-1416
Published Online:19 November 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Journal of Mathematical Biology 78(5): 1277-1298
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
694461EPSRC Centre for Multiscale soft tissue mechanics with application to heart & cancerRaymond OgdenEngineering and Physical Sciences Research Council (EPSRC)EP/N014642/1M&S - MATHEMATICS