Ideal cardiovascular health and incident cardiovascular disease among adults: a systematic review and meta-analysis

Ramírez-Vélez, R., Saavedra, J. M., Lobelo, F., Celis-Morales, C. A. , Pozo-Cruz, B. d. and García-Hermoso, A. (2018) Ideal cardiovascular health and incident cardiovascular disease among adults: a systematic review and meta-analysis. Mayo Clinic Proceedings, 93(11), pp. 1589-1599. (doi:10.1016/j.mayocp.2018.05.035) (PMID:30274906)

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Abstract

Objective: To investigate the association between ideal cardiovascular health (CVH) metrics and incident cardiovascular disease (CVD) by conducting a systematic review and meta-analysis of prospective cohort studies. Methods: The MEDLINE, EMBASE, and CINAHL databases were searched from January 1, 2010 through July 31, 2017, for studies that met the following criteria: (1) prospective studies conducted in adults, (2) with outcome data on CVD incidence and (3) a measure of ideal CVH metrics. Results: Twelve studies (210,443 adults) were included in this analysis. Compared with adults who met 0 to 2 of the ideal CVH metrics (high-risk individuals), a significantly lower hazard for CVD incidence was observed in those who had 3 to 4 points for the ideal CVH metrics (hazard ratio [HR]=0.53; 95% CI, 0.47-0.59) and 5 to 7 points (HR=0.28; 95% CI, 0.23-0.33). Weaker associations were observed in studies with older individuals, suggesting that there is a positive relationship between age and HR. Conclusion: Although meeting 5 to 7 metrics is associated with the lowest hazard for CVD incidence, meeting 3 to 4 metrics still offers an important protective effect for CVD. Therefore, a realistic goal in the general population in the short term could be to promote at least an intermediate ideal CVH profile (3 to 4 metrics).

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Celis, Dr Carlos
Authors: Ramírez-Vélez, R., Saavedra, J. M., Lobelo, F., Celis-Morales, C. A., Pozo-Cruz, B. d., and García-Hermoso, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Mayo Clinic Proceedings
Publisher:Elsevier
ISSN:0025-6196
ISSN (Online):1942-5546
Published Online:28 September 2018
Copyright Holders:Copyright © 2018 Mayo Foundation for Medical Education and Research
First Published:First published in Mayo Clinic Proceedings 93(11): 1589-1599
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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