Ideal cardiovascular health and incident cardiovascular disease among adults: a systematic review and meta-analysis

Ramírez-Vélez, R., Saavedra, J. M., Lobelo, F., Celis-Morales, C. A. , Pozo-Cruz, B. d. and García-Hermoso, A. (2018) Ideal cardiovascular health and incident cardiovascular disease among adults: a systematic review and meta-analysis. Mayo Clinic Proceedings, 93(11), pp. 1589-1599. (doi: 10.1016/j.mayocp.2018.05.035) (PMID:30274906)

Abstract

Objective: To investigate the association between ideal cardiovascular health (CVH) metrics and incident cardiovascular disease (CVD) by conducting a systematic review and meta-analysis of prospective cohort studies. Methods: The MEDLINE, EMBASE, and CINAHL databases were searched from January 1, 2010 through July 31, 2017, for studies that met the following criteria: (1) prospective studies conducted in adults, (2) with outcome data on CVD incidence and (3) a measure of ideal CVH metrics. Results: Twelve studies (210,443 adults) were included in this analysis. Compared with adults who met 0 to 2 of the ideal CVH metrics (high-risk individuals), a significantly lower hazard for CVD incidence was observed in those who had 3 to 4 points for the ideal CVH metrics (hazard ratio [HR]=0.53; 95% CI, 0.47-0.59) and 5 to 7 points (HR=0.28; 95% CI, 0.23-0.33). Weaker associations were observed in studies with older individuals, suggesting that there is a positive relationship between age and HR. Conclusion: Although meeting 5 to 7 metrics is associated with the lowest hazard for CVD incidence, meeting 3 to 4 metrics still offers an important protective effect for CVD. Therefore, a realistic goal in the general population in the short term could be to promote at least an intermediate ideal CVH profile (3 to 4 metrics).

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Celis, Dr Carlos
• Authors: Ramírez-Vélez, R., Saavedra, J. M., Lobelo, F., Celis-Morales, C. A., Pozo-Cruz, B. d., and García-Hermoso, A.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Mayo Clinic Proceedings
• Publisher: Elsevier
• ISSN: 0025-6196
• ISSN (Online): 1942-5546
• Published Online: 28 September 2018
• Copyright Holders: Copyright © 2018 Mayo Foundation for Medical Education and Research
• First Published: First published in Mayo Clinic Proceedings 93(11): 1589-1599
• Publisher Policy: Reproduced in accordance with the publisher copyright policy