Water-compatible synthesis of 2-trifluoromethyl-1,3-dioxanes

Becerra-Figueroa, L., Tiniakos, A. F., Prunet, J. and Gamba-Sánchez, D. A. (2018) Water-compatible synthesis of 2-trifluoromethyl-1,3-dioxanes. European Journal of Organic Chemistry, 48, pp. 6929-6932. (doi: 10.1002/ejoc.201801367)

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A water-compatible method for the diastereoselective synthesis of 2-trifluormethyl-1,3-dioxanes is described. The reaction proceeds under mild reaction conditions using simple inorganic bases; it has a very good substrate scope and can be performed with different Michael acceptors. Additionally, the reaction products can be further functionalized, showing an excellent perspective for future applications.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Tiniakos, Mr Alexander and Prunet, Dr Joelle
Authors: Becerra-Figueroa, L., Tiniakos, A. F., Prunet, J., and Gamba-Sánchez, D. A.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:European Journal of Organic Chemistry
ISSN (Online):1099-0690
Published Online:19 October 2018
Copyright Holders:Copyright © 2018 Wiley-VCH Verlag GmbH and Co. KGaA
First Published:First published in European Journal of Organic Chemistry 48:6929-6932
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
608951Engineering and Physical Sciences Doctoral Training Grant 2012-16Mary Beth KneafseyEngineering and Physical Sciences Research Council (EPSRC)EP/K503058/1VPO VICE PRINCIPAL RESEARCH & ENTERPRISE