Sporadic gastric cancer; a complex interaction of genetic and environmental risk factors

McColl, K., Watabe, H. and Derakhshan, M. (2007) Sporadic gastric cancer; a complex interaction of genetic and environmental risk factors. American Journal of Gastroenterology, 102(9), pp. 1893-1895.

Full text not currently available from Enlighten.

Abstract

Sporadic gastric cancer usually arises against a background of sequential mucosal changes. H. pylori superficial gastritis progresses to atrophy and intestinal metaplasia and then to dysplasia and cancer. A variety of environmental and host genetic factors influence this process and act at different stages in the pathway. Many different combinations of these risk factors may lead to cancer. Interactions also occur between environmental and genetic factors to increase or decrease their ability to influence the precancerous process. Sporadic gastric cancer is thus the consequence of complex combinations and interactions between many environmental and genetic factors.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McColl, Professor Kenneth and Derakhshan, Dr Mohammad
Authors: McColl, K., Watabe, H., and Derakhshan, M.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:American Journal of Gastroenterology
Publisher:Nature Publishing Group
ISSN:0002-9270

University Staff: Request a correction | Enlighten Editors: Update this record