Casson, J., Davies, O. G., Smith, C.-A. , Dalby, M. J. and Berry, C. C. (2018) Mesenchymal stem cell-derived extracellular vesicles may promote breast cancer cell dormancy. Journal of Tissue Engineering, 9, p. 2041731418810093. (doi: 10.1177/2041731418810093) (PMID:30627418) (PMCID:PMC6311537)
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Abstract
Disseminated breast cancer cells have the capacity to metastasise to the bone marrow and reside in a dormant state within the mesenchymal stem cell niche. Research has focussed on paracrine signalling factors, such as soluble proteins, within the microenvironment. However, it is now clear extracellular vesicles secreted by resident mesenchymal stem cells into this microenvironment also play a key role in the initiation of dormancy. Dormancy encourages reduced cell proliferation and migration, while upregulating cell adhesion, thus retaining the cancer cells within the bone marrow microenvironment. Here, MCF7 breast cancer cells were treated with mesenchymal stem cell–derived extracellular vesicles, resulting in reduced migration in two-dimensional and three-dimensional culture, with reduced cell proliferation and enhanced adhesion, collectively supporting cancer cell dormancy.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Berry, Dr Catherine and Dalby, Professor Matthew and Casson, Jake and Smith, Mrs Carol-Anne |
Authors: | Casson, J., Davies, O. G., Smith, C.-A., Dalby, M. J., and Berry, C. C. |
College/School: | College of Medical Veterinary and Life Sciences > School of Molecular Biosciences |
Journal Name: | Journal of Tissue Engineering |
Publisher: | SAGE Publications |
ISSN: | 2041-7314 |
ISSN (Online): | 2041-7314 |
Published Online: | 25 December 2018 |
Copyright Holders: | Copyright © 2018 The Authors |
First Published: | First published in Journal of Tissue Engineering 9: 2041731418810093 |
Publisher Policy: | Reproduced under a Creative Commons License |
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