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Preferential retention of codon 72 arginine p53 in squamous cell carcinomas of the vulva occurs in cancers positive and negative for human papillomavirus

Brooks, L., Tidy, J., Gusterson, B., Hiller, L., O'Nions, J., Gasco, M., Marin, M., Farrell, P., Kaelin, W., and Crook, T. (2000) Preferential retention of codon 72 arginine p53 in squamous cell carcinomas of the vulva occurs in cancers positive and negative for human papillomavirus. Cancer Research, 60 (24). pp. 6875-6877. ISSN 0008-5472

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Abstract

We have sought to determine the basis for preferential loss of the codon 72 proline (72P) rather than the arginine (72R) allele in squamous cell carcinoma of the vulva with loss of heterozygosity (LOH) in p53, The proportion of eases containing human papillomavirus (HPV) 16 was not statistically different among. individuals with either 72RR or 72RP in the germ line (P > 0.99), but p53 LOH was significantly more common in individuals heterozygous 72RP than in 72RR individuals (P = 0.04). LOH more commonly involved the 72P allele in both HPV-positive and HPV-negative cancers. Our results imply that preferential loss of the 72P allele in vulval squamous fell carcinoma occurs by HPV-dependent and -independent mechanisms.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gusterson, Prof Barry
Authors: Brooks, L., Tidy, J., Gusterson, B., Hiller, L., O'Nions, J., Gasco, M., Marin, M., Farrell, P., Kaelin, W., and Crook, T.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Cancer Research
ISSN:0008-5472

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