Investigating the relationship between cerebral blood flow and cognitive function in hemodialysis patients

Findlay, M. D., Dawson, J. , Dickie, D. A. , Forbes, K. P., McGlynn, D., Quinn, T. and Mark, P. B. (2019) Investigating the relationship between cerebral blood flow and cognitive function in hemodialysis patients. Journal of the American Society of Nephrology, 30(10194), pp. 147-158. (doi:10.1681/ASN.2018050462) (PMID:30530658)

[img]
Preview
Text
171016.pdf - Accepted Version

863kB
[img]
Preview
Text
171016Suppl.pdf - Supplemental Material

723kB

Abstract

Background: The immediate and longer-term effects of hemodialysis on cerebral circulation, cerebral structure, and cognitive function are poorly understood. Methods: In a prospective observational cohort study of 97 adults (median age 59 years) receiving chronic hemodialysis, we used transcranial Doppler ultrasound to measure cerebral arterial mean flow velocity (MFV) throughout dialysis. Using a well validated neuropsychological protocol, we assessed cognitive function during and off dialysis and after 12 months of treatment. We also used brain magnetic resonance imaging (MRI) to assess atrophy, white matter hyperintensities (WMHs), and diffusion parameters, and tested correlations between MFV, cognitive scores, and changes on MRI. Results: MFV declined significantly during dialysis, correlating with ultrafiltrate volumes. Percentage of decline in MFV correlated with intradialytic decline in cognitive function, including global function, executive function, and verbal fluency. At follow-up, 73 patients were available for repeat testing, 34 of whom underwent repeat MRI. In a subgroup of patients followed for 12 months of continued dialysis, percentage of decline in MFV correlated significantly with lower global and executive function and with progression of WMH burden (a marker of small vessel disease). Twelve of 15 patients who received renal transplants during follow-up had both early and follow-up off-dialysis assessments. After transplant, patients’ memory (on a delayed recall test) improved significantly; increased fractional anisotropy of white matter (a measure of cerebral diffusion) in these patients correlated with improving executive function. Conclusions: Patients undergoing hemodialysis experience transient decline in cerebral blood flow, correlating with intradialytic cognitive dysfunction. Progressive cerebrovascular disease occurred in those continuing dialysis, but not in transplanted patients. Cognitive function and cerebral diffusion improved after transplant.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Quinn, Dr Terence and Mark, Dr Patrick and Dawson, Professor Jesse and Findlay, Dr Mark and Forbes, Dr Kirsten and Dickie, Dr David Alexander
Authors: Findlay, M. D., Dawson, J., Dickie, D. A., Forbes, K. P., McGlynn, D., Quinn, T., and Mark, P. B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Journal of the American Society of Nephrology
Publisher:American Society of Nephrology
ISSN:1046-6673
ISSN (Online):1533-3450
Published Online:07 December 2018
Copyright Holders:Copyright © 2018 American Society of Nephrology
First Published:First published in Journal of the American Society of Nephrology 2018
Publisher Policy:Reproduced in accordance with the publisher copyright policy

University Staff: Request a correction | Enlighten Editors: Update this record