A spectroscopic tool based on an interference filter and birefringent prisms: demonstration of detection of 5-aminolaevulinic acid-induced protoporphyrin IX fluorescence

O'Dwyer, M., Nadeau, V. and Padgett, M. (2003) A spectroscopic tool based on an interference filter and birefringent prisms: demonstration of detection of 5-aminolaevulinic acid-induced protoporphyrin IX fluorescence. Journal of Physics D: Applied Physics, 36(14), 1703 -1706. (doi:10.1088/0022-3727/36/14/308)

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Publisher's URL: http://dx.doi.org/10.1088/0022-3727/36/14/308

Abstract

We describe a differential fluorescence detection system that consists of a 405 nm diode laser for fluorescence excitation, a bifurcated fibre for delivery of light to and collection of light from tissue, birefringent prisms and a tilted filter. This instrument is optimized for the selective detection of protoporphyrin IX fluorescence and autofluorescence from tissue, and its effectiveness demonstrated using low excitation light levels (0.7 mW cm/sup -2/).

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Padgett, Professor Miles
Authors: O'Dwyer, M., Nadeau, V., and Padgett, M.
Subjects:Q Science > QC Physics
College/School:College of Science and Engineering > School of Physics and Astronomy
Journal Name:Journal of Physics D: Applied Physics
ISSN:0022-3727

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