Low praziquantel treatment coverage for Schistosoma mansoni in Mayuge District, Uganda due to the absence of treatment opportunities, rather than systematic non-compliance

Adriko, M., Faust, C. L. , Carruthers, L. V. , Moses, A., Tukahebwa, E. M. and Lamberton, P. H.L. (2018) Low praziquantel treatment coverage for Schistosoma mansoni in Mayuge District, Uganda due to the absence of treatment opportunities, rather than systematic non-compliance. Tropical Medicine and Infectious Disease, 3(4), 111. (doi:10.3390/tropicalmed3040111) (PMID:30297642) (PMCID:PMC6306755)

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Abstract

The World Health Organization (WHO) recommends praziquantel mass drug administration (MDA) to control schistosomiasis in endemic regions. We aimed to quantify recent and lifetime praziquantel coverage, and reasons for non-treatment, at an individual level to guide policy recommendations to help Uganda reach WHO goals. Cross-sectional household surveys (n = 681) encompassing 3208 individuals (adults and children) were conducted in 2017 in Bugoto A and B, Mayuge District, Uganda. Participants were asked if they had received praziquantel during the recent MDA (October 2016) and whether they had ever received praziquantel in their lifetime. A multivariate logistic regression analysis with socio-economic and individual characteristics as covariates was used to determine factors associated with praziquantel uptake. In the MDA eligible population (≥5 years of age), the most recent MDA coverage was 48.8%. Across individuals’ lifetimes, 31.8% of eligible and 49.5% of the entire population reported having never taken praziquantel. Factors that improved individuals’ odds of taking praziquantel included school enrolment, residence in Bugoto B and increasing years of village-residency. Not being offered (49.2%) and being away during treatment (21.4%) were the most frequent reasons for not taking the 2016 praziquantel MDA. Contrary to expectations, chronically-untreated individuals were rarely systematic non-compliers, but more commonly not offered treatment.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Carruthers, Lauren and Lamberton, Dr Poppy and Faust, Christina
Authors: Adriko, M., Faust, C. L., Carruthers, L. V., Moses, A., Tukahebwa, E. M., and Lamberton, P. H.L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Tropical Medicine and Infectious Disease
Publisher:MDPI
ISSN:2414-6366
ISSN (Online):2414-6366
Published Online:08 October 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Tropical Medicine and Infectious Disease 3(4): 111
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
730161SCHISTO-PERSISTPoppy LambertonEuropean Research Council (ERC)680088RI BIODIVERSITY ANIMAL HEALTH & COMPMED