Relationship between nutritional status and the systemic inflammatory response: micronutrients

McMillan, D. C. , Maguire, D. and Talwar, D. (2018) Relationship between nutritional status and the systemic inflammatory response: micronutrients. Proceedings of the Nutrition Society, 78(1), pp. 56-67. (doi:10.1017/S0029665118002501) (PMID:30220267)

Full text not currently available from Enlighten.


Micronutrients such as trace elements and vitamins are important as enzyme cofactors in the metabolism of all cells in the body and therefore key to determining nutritional status. The present systematic review examined the evidence of the impact of the systemic inflammatory response on plasma micronutrient status in acute (surgical) and chronic tissue injury. A literature review using targeted subject headings was carried out. Plasma C-reactive protein was used to classify minor (80 mg/l) inflammation. The literature search produced 2344 publications and plasma vitamin D, zinc and carotenoids were most commonly studied and plasma vitamins K, B2 and B6 were least studied. In acute injury thirteen studies (all prospective) and in chronic injury twenty-four studies (largely retrospective) were included in the review. There was consistent evidence that most common measured micronutrients in the plasma (zinc, selenium, vitamins A, D, E, K, B2, B6, B12, C, lutein, lycopene, α- and β-carotene) were significantly lowered from minor to moderate to major inflammation. The results of the present systematic review indicate that most plasma micronutrients fall as part of the systemic inflammatory response irrespective of acute or chronic injury. Therefore, in the presence of a systemic inflammation, plasma micronutrient concentrations should be interpreted with caution. There are a number of methods applied to adjust plasma micronutrient concentrations to avoid misdiagnosis of deficiency. Alternatively, intracellular measurements appear to obviate the need for such plasma adjustment to assess micronutrient status.

Item Type:Articles
Additional Information:The work has been supported by funding from the University of Glasgow, Glasgow Royal Infirmary Endowment Funds, the Chief Scientist Office and Cancer Research, UK.
Glasgow Author(s) Enlighten ID:McMillan, Professor Donald
Authors: McMillan, D. C., Maguire, D., and Talwar, D.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Proceedings of the Nutrition Society
Publisher:Cambridge University Press
ISSN (Online):1475-2719

University Staff: Request a correction | Enlighten Editors: Update this record