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Acetyltransferases and tumour suppression

Phillips, A.C., and Vousden, K.H. (2000) Acetyltransferases and tumour suppression. Breast Cancer Research, 2 (4). pp. 244-246. ISSN 1465-5411 (doi:10.1186/bcr63)

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Abstract

The acetyltransferase p300 was first identified associated with the adenoviral transforming protein E1A, suggesting a potential role for p300 in the regulation of cell proliferation. Direct evidence demonstrating a role for p300 in human tumours was lacking until the recently publication by Gayther et al, which strongly supports a role for p300 as a tumour suppressor. The authors identify truncating mutations associated with the loss or mutation of the second allele in both tumour samples and cell lines, suggesting that loss of p300 may play a role in the development of a subset of human cancers.

Item Type:Article
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Vousden, Prof Karen
Authors: Phillips, A.C., and Vousden, K.H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Breast Cancer Research
Publisher:Biomed Central
ISSN:1465-5411
ISSN (Online):1465-542X

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