Phillips, A.C. and Vousden, K.H. (2000) Acetyltransferases and tumour suppression. Breast Cancer Research, 2(4), pp. 244-246. (doi: 10.1186/bcr63)
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Abstract
The acetyltransferase p300 was first identified associated with the adenoviral transforming protein E1A, suggesting a potential role for p300 in the regulation of cell proliferation. Direct evidence demonstrating a role for p300 in human tumours was lacking until the recently publication by Gayther et al, which strongly supports a role for p300 as a tumour suppressor. The authors identify truncating mutations associated with the loss or mutation of the second allele in both tumour samples and cell lines, suggesting that loss of p300 may play a role in the development of a subset of human cancers.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Vousden, Karen |
| Authors: | Phillips, A.C., and Vousden, K.H. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Breast Cancer Research |
| Publisher: | Biomed Central |
| ISSN: | 1465-5411 |
| ISSN (Online): | 1465-542X |
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