Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids

Damasceno, J. D. , Silva, G. L.A., Tschudi, C. and Tosi, L. R.O. (2017) Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids. Memorias Do Instituto Oswaldo Cruz, 112(8), pp. 572-576. (doi: 10.1590/0074-02760170054) (PMID:28767983) (PMCID:PMC5530550)

Abstract

The Telomeric Repeat-containing RNAs (TERRA) participate in the homeostasis of telomeres in higher eukaryotes. Here, we investigated the expression of TERRA in Leishmania spp. and Trypanosoma brucei and found evidences for its expression as a specific RNA class. The trypanosomatid TERRA are heterogeneous in size and partially polyadenylated. The levels of TERRA transcripts appear to be modulated through the life cycle in both trypanosomatids investigated, suggesting that TERRA play a stage-specific role in the life cycle of these early-branching eukaryotes.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Damasceno, Dr Jeziel
• Authors: Damasceno, J. D., Silva, G. L.A., Tschudi, C., and Tosi, L. R.O.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Memorias Do Instituto Oswaldo Cruz
• Publisher: Instituto Oswaldo Cruz
• ISSN: 0074-0276
• ISSN (Online): 1678-8060
• Copyright Holders: Copyright © 2017 The Authors
• First Published: First published in Memorias Do Instituto Oswaldo Cruz 112(8): 572-576
• Publisher Policy: Reproduced under a Creative Commons License