Aggarwal, A. , Rudnick, J., Bruinsma, R.F. and Klug, W.S. (2012) Elasticity theory of macromolecular aggregates. Physical Review Letters, 109, 148102. (doi: 10.1103/PhysRevLett.109.148102) (PMID:23083291)
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Abstract
We present a version of continuum elasticity theory applicable to aggregates of functional biomolecules at length scales comparable to that of the component molecules. Unlike classical elasticity theory, the stress and strain fields have mathematical discontinuities along the interfaces of the macromolecules, due to conformational incompatibility and large scale conformational transitions. The method is applied to the P-II to EI shape transition of the protein shell of the virus HK97. We show that protein residual stresses generated by incompatibility drive a “reverse buckling” transition from an icosahedral to a dodecahedral shape via a “critical” spherical shape, which can be identified as the P-II state.
| Item Type: | Articles |
|---|---|
| Additional Information: | The authors gratefully acknowledge support from NSF Grant No. DMR-1006128. W. S. K. acknowledges partial support from NSF Grant No. CMMI-0748034. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Aggarwal, Dr Ankush |
| Authors: | Aggarwal, A., Rudnick, J., Bruinsma, R.F., and Klug, W.S. |
| College/School: | College of Science and Engineering > School of Engineering > Infrastructure and Environment |
| Journal Name: | Physical Review Letters |
| Publisher: | American Physical Society |
| ISSN: | 0031-9007 |
| ISSN (Online): | 1079-7114 |
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