Spline Based Microstructural Mapping for Soft Biological Tissues: Application to Aortic Valves

Aggarwal, A. , Aguilar, V.S., Lee, C.H., Ferrari, G., Gorman, J.H., Gorman, R.C. and Sacks, M.S. (2013) Spline Based Microstructural Mapping for Soft Biological Tissues: Application to Aortic Valves. In: ASME 2013 Summer Bioengineering Conference, SBC 2013, Sunriver, Oregon, 26-29 June 2013, V01AT04A006. (doi: 10.1115/SBC2013-14265)

Abstract

Splines are the standard tools in computer aided design for geometric representations and have been recently integrated into the finite element analysis of structures and fluids [1]. As the biomedical engineering is making progress, there is a need for an integrated tool for expanding the geometrical representation to include the microstructural details specific to soft tissue, e.g. fiber alignment, orientation, crimp and stiffness. In this work, a spline-based method is presented for aortic valves which facilitates mapping of the fiber structure from any aortic valve specimen to any other aortic valve geometry through a common parameter space. This techniques also has the ability to calculate mean tissue microstructure of representative population. Also strain and pre-strain from in-vivo state to the in-vitro state, where all the mechanical tests are done, are calculated for forward and inverse modeling of aortic valves.

• Item Type: Conference Proceedings
• Additional Information: We gratefully acknowledge the support funds from following sources – NIH Grant HL108330 and Moncrief Chair funds (M.S.S.), ICES postdoctoral fellowship (C.H.L.) and NIH Grants HL63954, HL103723 and HL73021 (R.C.G. and J.H.G.).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Aggarwal, Dr Ankush
• Authors: Aggarwal, A., Aguilar, V.S., Lee, C.H., Ferrari, G., Gorman, J.H., Gorman, R.C., and Sacks, M.S.
• College/School: College of Science and Engineering > School of Engineering > Infrastructure and Environment