Culex tarsalis is a competent vector species for Cache Valley virus

Ayers, V. B. et al. (2018) Culex tarsalis is a competent vector species for Cache Valley virus. Parasites and Vectors, 11, 519. (doi:10.1186/s13071-018-3103-2) (PMID:30236148) (PMCID:PMC6149065)

[img]
Preview
Text
169701.pdf - Published Version
Available under License Creative Commons Attribution.

604kB

Abstract

Background: Cache Valley virus (CVV) is a mosquito-borne orthobunyavirus endemic in North America. The virus is an important agricultural pathogen leading to abortion and embryonic lethality in ruminant species, especially sheep. The importance of CVV in human public health has recently increased because of the report of severe neurotropic diseases. However, mosquito species responsible for transmission of the virus to humans remain to be determined. In this study, vector competence of three Culex species mosquitoes of public health importance, Culex pipiens, Cx. tarsalis and Cx. quinquefasciatus, was determined in order to identify potential bridge vector species responsible for the transmission of CVV from viremic vertebrate hosts to humans. Results: Variation of susceptibility to CVV was observed among selected Culex species mosquitoes tested in this study. Per os infection resulted in the establishment of infection and dissemination in Culex tarsalis, whereas Cx. pipiens and Cx. quinquefasciatus were highly refractory to CVV. Detection of viral RNA in saliva collected from infected Cx. tarsalis provided evidence supporting its role as a competent vector. Conclusions: Our study provided further understanding of the transmission cycles of CVV and identifies Cx. tarsalis as a competent vector.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Dunlop, Dr James and Kohl, Professor Alain
Authors: Ayers, V. B., Huang, Y.-J., Lyons, A. C., Park, S. L., Higgs, S., Dunlop, J. I., Kohl, A., Alto, B. W., Unlu, I., Blitvich, B. J., and Vanlandingham, D. L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Parasites and Vectors
Publisher:BioMed Central
ISSN:1756-3305
ISSN (Online):1756-3305
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Parasites and Vectors 11: 519
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
670431US-UK BBSRC-NIFA Collab: Control of emerging bunyavirusesAlain KohlBiotechnology and Biological Sciences Research Council (BBSRC)BB/M027112/1MVLS III - CENTRE FOR VIRUS RESEARCH
709011Quinquennial Core FundsMassimo PalmariniMedical Research Council (MRC)MC_UU_12014/9MVLS III - CENTRE FOR VIRUS RESEARCH