Comparative genomics of the major parasitic worms

International Helminth Genomes Consortium, et al. (2019) Comparative genomics of the major parasitic worms. Nature Genetics, 51(1), pp. 163-174. (doi:10.1038/s41588-018-0262-1) (PMID:30397333) (PMCID:PMC6349046)

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Abstract

Parasitic nematodes (roundworms) and platyhelminths (flatworms) cause debilitating chronic infections of humans and animals, decimate crop production and are a major impediment to socioeconomic development. Here we report the broadest comparative study to date of the genomes of parasitic and non-parasitic worms, involving 81. We have identified gene family births and hundreds of expanded gene families at key nodes in the phylogeny that are relevant to parasitism. Examples include gene families that modulate host immune responses, enable parasite migration though host tissues or allow the parasite to feed. We reveal extensive lineage-specific differences in core metabolism and protein families historically targeted for drug development. From an in silico screen, we have identified and prioritised new potential drug targets and compounds for testing. This comparative genomics resource provides a much needed boost for the research community to understand and combat parasitic worms.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Devaney, Professor Eileen and Babayan, Dr Simon and Maizels, Professor Richard
Authors: International Helminth Genomes Consortium, , Coghlan, A., Tyagi, R., Cotton, J. A., Holroyd, N., Rosa, B. A., Tsai, I. J., Laetsch, D. R., Beech, R. N., Day, T. A., Hallsworth-Pepin, K., Ke, H.-M., Kuo, T.-H., Lee, T. J., Martin, J., Maizels, R. M., Mutowo, P., Ozersky, P., Parkinson, J., Reid, A. J., Rawlings, N. D., Ribeiro, D. M., Seshadri, S. L., Stanley, E., Taylor, D. W., Wheeler, N. J., Zamanian, M., Zhang, X., Allan, F., Allen, J. E., Asano, K., Babayan, S. A., Bah, G., Beasley, H., Bennett, H. M., Bisset, S. A., Castillo, E., Cook, J., Cooper, P. J., Cruz-Bustos, T., Cuéllar, C., Devaney, E., Doyle, S. R., Eberhard, M. L., Emery, A., Eom, K. S., Gilleard, J. S., Gordon, D., Harcus, Y., Harsha, B., Hawdon, J. M., Hill, D. E., Hodgkinson, J., Horák, P., Howe, K. L., Huckvale, T., Kalbe, M., Kaur, G., Kikuchi, T., Koutsovoulos, G., Kumar, S., Leach, A. R., Lomax, J., Makepeace, B., Matthews, J. B., Muro, A., O'Boyle, N. M., Olson, P. D., Osuna, A., Partono, F., Pfarr, K., Rinaldi, G., Foronda, P., Rollinson, D., Samblas, M. G., Sato, H., Schnyder, M., Scholz, T., Shafie, M., Tanya, V. N., Toledo, R., Tracey, A., Urban, J. F., Wang, L.-C., Zarlenga, D., Blaxter, M. L., Mitreva, M., and Berriman, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Nature Genetics
Publisher:Nature Research
ISSN:1061-4036
ISSN (Online):1546-1718
Published Online:05 November 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Nature Genetics 51(1): 163-174
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
765221Helminths and the Immune System: Regulation, Regulators and ImmunityRichard MaizelsWellcome Trust (WELLCOTR)106122/A/14/ZIII - PARASITOLOGY
371799The Wellcome Centre for Molecular Parasitology ( Core Support )Andrew WatersWellcome Trust (WELLCOTR)104111/Z/14/Z & AIII - PARASITOLOGY