International Helminth Genomes Consortium, et al. (2019) Comparative genomics of the major parasitic worms. Nature Genetics, 51(1), pp. 163-174. (doi: 10.1038/s41588-018-0262-1) (PMID:30397333) (PMCID:PMC6349046)
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Abstract
Parasitic nematodes (roundworms) and platyhelminths (flatworms) cause debilitating chronic infections of humans and animals, decimate crop production and are a major impediment to socioeconomic development. Here we report the broadest comparative study to date of the genomes of parasitic and non-parasitic worms, involving 81. We have identified gene family births and hundreds of expanded gene families at key nodes in the phylogeny that are relevant to parasitism. Examples include gene families that modulate host immune responses, enable parasite migration though host tissues or allow the parasite to feed. We reveal extensive lineage-specific differences in core metabolism and protein families historically targeted for drug development. From an in silico screen, we have identified and prioritised new potential drug targets and compounds for testing. This comparative genomics resource provides a much needed boost for the research community to understand and combat parasitic worms.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Devaney, Professor Eileen and Cotton, Professor James and Babayan, Dr Simon and Maizels, Professor Rick |
| Authors: | International Helminth Genomes Consortium, , Coghlan, A., Tyagi, R., Cotton, J. A., Holroyd, N., Rosa, B. A., Tsai, I. J., Laetsch, D. R., Beech, R. N., Day, T. A., Hallsworth-Pepin, K., Ke, H.-M., Kuo, T.-H., Lee, T. J., Martin, J., Maizels, R. M., Mutowo, P., Ozersky, P., Parkinson, J., Reid, A. J., Rawlings, N. D., Ribeiro, D. M., Seshadri, S. L., Stanley, E., Taylor, D. W., Wheeler, N. J., Zamanian, M., Zhang, X., Allan, F., Allen, J. E., Asano, K., Babayan, S. A., Bah, G., Beasley, H., Bennett, H. M., Bisset, S. A., Castillo, E., Cook, J., Cooper, P. J., Cruz-Bustos, T., Cuéllar, C., Devaney, E., Doyle, S. R., Eberhard, M. L., Emery, A., Eom, K. S., Gilleard, J. S., Gordon, D., Harcus, Y., Harsha, B., Hawdon, J. M., Hill, D. E., Hodgkinson, J., Horák, P., Howe, K. L., Huckvale, T., Kalbe, M., Kaur, G., Kikuchi, T., Koutsovoulos, G., Kumar, S., Leach, A. R., Lomax, J., Makepeace, B., Matthews, J. B., Muro, A., O'Boyle, N. M., Olson, P. D., Osuna, A., Partono, F., Pfarr, K., Rinaldi, G., Foronda, P., Rollinson, D., Samblas, M. G., Sato, H., Schnyder, M., Scholz, T., Shafie, M., Tanya, V. N., Toledo, R., Tracey, A., Urban, J. F., Wang, L.-C., Zarlenga, D., Blaxter, M. L., Mitreva, M., and Berriman, M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Research Centre: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology |
| Journal Name: | Nature Genetics |
| Publisher: | Nature Research |
| ISSN: | 1061-4036 |
| ISSN (Online): | 1546-1718 |
| Published Online: | 05 November 2018 |
| Copyright Holders: | Copyright © 2018 The Authors |
| First Published: | First published in Nature Genetics 51(1): 163-174 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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