Sphingosine Kinases promote IL-17 expression in human T lymphocytes

Barra, G. et al. (2018) Sphingosine Kinases promote IL-17 expression in human T lymphocytes. Scientific Reports, 8, 13233. (doi:10.1038/s41598-018-31666-1) (PMID:30185808) (PMCID:PMC6125344)

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Abstract

Sphingosine 1-phosphate (S1P) has a role in many cellular processes. S1P is involved in cell growth and apoptosis, regulation of cell trafficking, production of cytokines and chemokines. The kinases SphK1 and SphK2 (SphKs) phosphorilate Sphingosine (Sph) to S1P and several phosphatases revert S1P to sphingosine, thus assuring a balanced pool that can be depleted by a Sphingosine lyase in hexadecenal compounds and aldehydes. There are evidences that SphK1 and 2 may per se control cellular processes. Here, we report that Sph kinases regulate IL-17 expression in human T cells. SphKs inhibition impairs the production of IL-17, while their overexpression up-regulates expression of the cytokine through acetylation of IL-17 promoter. SphKs were up-regulated also in PBMCs of patients affected by IL-17 related diseases. Thus, S1P/S1P kinases axis is a mechanism likely to promote IL-17 expression in human T cells, representing a possible therapeutic target in human inflammatory diseases.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Somma, Domenico
Authors: Barra, G., Lepore, A., Gagliardi, M., Somma, D., Matarazzo, M. R., Costabile, F., Pasquale, G., Mazzoni, A., Gallo, C., Nuzzo, G., Annunziato, F., Fontana, A., Leonardi, A., and De Palma, R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Scientific Reports
Publisher:Nature Publishing Group
ISSN:2045-2322
ISSN (Online):2045-2322
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Scientific Reports 8: 13233
Publisher Policy:Reproduced under a Creative Commons License

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