Borderline Q-waves in individuals without overt cardiovascular disease: relations with adiposity, subclinical atherosclerosis and vascular stiffness

Elffers, T.W., Trompet, S., de Mutsert, R., Maan, A.C., Lamb, H.J., Macfarlane, P.W., Rosendaal, F.R. and Jukema, J.W. (2019) Borderline Q-waves in individuals without overt cardiovascular disease: relations with adiposity, subclinical atherosclerosis and vascular stiffness. International Journal of Cardiology, 274, pp. 331-336. (doi:10.1016/j.ijcard.2018.08.088) (PMID:30195838)

Elffers, T.W., Trompet, S., de Mutsert, R., Maan, A.C., Lamb, H.J., Macfarlane, P.W., Rosendaal, F.R. and Jukema, J.W. (2019) Borderline Q-waves in individuals without overt cardiovascular disease: relations with adiposity, subclinical atherosclerosis and vascular stiffness. International Journal of Cardiology, 274, pp. 331-336. (doi:10.1016/j.ijcard.2018.08.088) (PMID:30195838)

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Abstract

Background: Characteristics and risk factors associated with electrocardiographic borderline Q-waves are not fully elucidated, especially in individuals without overt cardiovascular disease (CVD). Also, the relation of isolated and non-isolated borderline Q-waves with subclinical atherosclerosis and vascular stiffness is unknown. Methods and results: We included 5746 Netherlands Epidemiology of Obesity study participants without overt CVD. Participants were divided in three groups: no Q-waves (93.7%), isolated (4.6%) and non-isolated borderline Q-waves (1.7%). Borderline Q-waves were defined as Minnesota Codes 1.2.x and 1.3.x and non-isolated as ≥1 of abnormal QRS axis, left ventricular hypertrophy or ST/T abnormalities. Several characteristics and measures of body fat were assessed. Vascular stiffness was assessed by pulse wave velocity (PWV) and subclinical atherosclerosis by carotid intima-media thickness (cIMT). Percentage of men, alcohol intake, blood pressure and fasting glucose concentrations were, compared with no Q-waves, higher in the isolated and highest in the non-isolated borderline Q-wave group. Isolated borderline Q-waves were associated with higher body mass index (difference compared with no Q-waves: 1.0 kg/m2; 95%CI: 0.3–1.7; p-value: 0.006), waist circumference (3.4 cm; 1.0–5.8; 0.005), and visceral adipose tissue (21.9 cm2; 7.4–36.3; 0.003) and differences were even larger for non-isolated borderline Q-waves. Compared with no Q-waves, non-isolated borderline Q-waves were associated with higher PWV (1.2 m/s; 0.4–2.0; 0.004) and cIMT (23.4 μm; 3.0–43.8; 0.024), whereas isolated borderline Q-waves were not. Conclusion: Cardiovascular risk factors and measures of body fat, especially abdominal adiposity, were higher in participants with isolated borderline Q-waves, compared with no Q-waves, and highest in the non-isolated borderline Q-wave group. Non-isolated borderline Q-waves were associated with subclinical atherosclerosis and vascular stiffness. Future studies should investigate potential added value of borderline Q-waves in CVD prediction.

Item Type:Articles
Additional Information:This work was supported by the participating Departments; the Division and the Board of Directors of the Leiden University Medical Centre, and by the Leiden University, Research Profile Area ‘Vascular and Regenerative Medicine’.
Keywords:Borderline Q-waves, subclinical atherosclerosis, vascular stiffness.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Macfarlane, Professor Peter
Authors: Elffers, T.W., Trompet, S., de Mutsert, R., Maan, A.C., Lamb, H.J., Macfarlane, P.W., Rosendaal, F.R., and Jukema, J.W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
Journal Name:International Journal of Cardiology
Publisher:Elsevier
ISSN:0167-5273
ISSN (Online):1874-1754
Published Online:01 September 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in International Journal of Cardiology 274: 331-336
Publisher Policy:Reproduced under a Creative Commons License

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