The role of gamma delta T lymphocytes in breast cancer: a review

Morrow, E., Roseweir, A. and Edwards, J. (2019) The role of gamma delta T lymphocytes in breast cancer: a review. Translational Research, 203, pp. 88-96. (doi: 10.1016/j.trsl.2018.08.005) (PMID:30194922)

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Gammadelta T (γδT) lymphocytes have provoked interest in oncology, particularly as regards their potential use in immunotherapy, because of their unique ability to recognise antigens without a requirement for major histocompatibility complex antigen presentation, and to quickly activate an anti-tumour response. However, work in some cancers has suggested that they also have pro-tumourigenic activity. Their role in breast cancer is unclear. This review outlines the evidence to date in in vitro studies, in vivo mouse models and in human studies regarding the role of γδT lymphocytes in breast cancer. We describe the seemingly opposing roles of the predominantly circulating Vγ9Vδ2 subtype, which can suppress tumour growth through direct cytotoxicity, induction of apoptosis and inhibition of angiogenesis, and the predominantly tumour-infiltrating γδ1 subtype which can promote tumour growth and spread through immunosuppressant effects. We summarise the evidence in breast cancer for the mechanisms of action of γδT lymphocytes and describe how factors in the tumour microenvironment may affect their function, polarising them towards a pro-tumourigenic, immune-suppressing role. We also describe the experience to date of γδT lymphocytes in immunotherapy for breast cancer and suggest the direction of work going forward, particularly as regards different breast cancer subtypes.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Edwards, Professor Joanne and Morrow, Dr Elizabeth and Roseweir, Dr Antonia
Authors: Morrow, E., Roseweir, A., and Edwards, J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Translational Research
ISSN (Online):1878-1810
Published Online:18 August 2018
Copyright Holders:Copyright © 2018 Elsevier Inc
First Published:First published in Translational Research 203:88-96
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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