Role of gut microbiota-generated short chain fatty acids in metabolic and cardiovascular health

Chambers, E. S., Preston, T. , Frost, G. and Morrison, D. J. (2018) Role of gut microbiota-generated short chain fatty acids in metabolic and cardiovascular health. Current Nutrition Reports, 7(4), pp. 198-206. (doi: 10.1007/s13668-018-0248-8) (PMID:30264354) (PMCID:PMC6244749)

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Purpose of this Review: This review assesses the latest evidence linking short-chain fatty acids (SCFA) with host metabolic health and cardiovascular disease (CVD) risk and presents the latest evidence on possible biological mechanisms. Recent Findings: SCFA have a range of effects locally in the gut and at both splanchnic and peripheral tissues which together appear to induce improved metabolic regulation and have direct and indirect effects on markers of CVD risk. Summary: SCFA produced primarily from the microbial fermentation of dietary fibre appear to be key mediators of the beneficial effects elicited by the gut microbiome. Not only does dietary fibre fermentation regulate microbial activity in the gut, SCFA also directly modulate host health through a range of tissue-specific mechanisms related to gut barrier function, glucose homeostasis, immunomodulation, appetite regulation and obesity. With the increasing burden of obesity worldwide, the role for gut microbiota-generated SCFA in protecting against the effects of energy dense diets offers an intriguing new avenue for regulating metabolic health and CVD risk.

Item Type:Articles
Additional Information:This article was enabled by support from the UK Biotechnology and Biological Sciences Research Council (BB/L004259/1, BB/H004815/1) and was supported by the NIHR CRF BRC at Imperial College (IC) Healthcare NHS Trust. The Division of Diabetes, Endocrinology and Metabolism and Investigative Medicine is funded by grants from the MRC, BBSRC, NIHR, an Integrative Mammalian Biology (IMB) Capacity Building Award, an FP7- HEALTH- 2009- 241592 EuroCHIP grant and is supported by the NIHR Biomedical Research Centre Funding Scheme. GF holds an NIHR Senior Investigator Award.
Glasgow Author(s) Enlighten ID:Preston, Professor Tom and Morrison, Dr Douglas
Authors: Chambers, E. S., Preston, T., Frost, G., and Morrison, D. J.
College/School:College of Science and Engineering > Scottish Universities Environmental Research Centre
Journal Name:Current Nutrition Reports
ISSN (Online):2161-3311
Published Online:28 September 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Current Nutrition Reports 7:198-206
Publisher Policy:Reproduced under a Creative Commons License

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