Baquero, P., Dawson, A. and Helgason, G. V. (2019) Autophagy and mitochondrial metabolism: insights into the role and therapeutic potential in chronic myeloid leukaemia. FEBS Journal, 286(7), pp. 1271-1283. (doi: 10.1111/febs.14659) (PMID:30222247)
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Abstract
Despite the development of selective BCR‐ABL‐targeting tyrosine kinase inhibitors (TKIs) transforming the management of chronic myeloid leukaemia (CML), therapy‐resistant leukaemic stem cells (LSCs) persist after TKI treatment and present an obstacle to a CML cure. Recently, we and others have made significant contributions to the field by unravelling survival dependencies in LSCs to work towards the goal of eradicating LSCs in CML patients. In this review, we describe these findings focusing on autophagy and mitochondrial metabolism, which have recently been uncovered as two essential processes for LSCs quiescence and survival, respectively. In addition, we discuss the therapeutic potential of autophagy and mitochondrial metabolism inhibition as a strategy to eliminate CML cells in patients where the resistance to TKI is driven by BCR‐ABL‐independent mechanism(s).
| Item Type: | Articles |
|---|---|
| Additional Information: | Also funded by Leuka; the Howat Foundation, Lady Tata Memorial Trust and Friends of Paul O'Gorman Leukaemia Research Centre. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Dawson, Ms Amy and Helgason, Professor Vignir and Baquero, Dr Pablo |
| Authors: | Baquero, P., Dawson, A., and Helgason, G. V. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | FEBS Journal |
| Publisher: | Wiley |
| ISSN: | 1742-464X |
| ISSN (Online): | 1742-4658 |
| Published Online: | 17 September 2018 |
| Copyright Holders: | Copyright © 2018 Federation of European Biochemical Societies |
| First Published: | First published in FEBS Journal 286(7): 1271-1283 |
| Publisher Policy: | Reproduced in accordance with the publisher copyright policy |
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