TGFβ, smooth muscle cells and coronary artery disease: a review

Low, E. L., Baker, A. H. and Bradshaw, A. C. (2019) TGFβ, smooth muscle cells and coronary artery disease: a review. Cellular Signalling, 53, pp. 90-101. (doi:10.1016/j.cellsig.2018.09.004) (PMID:30227237)

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Abstract

Excessive vascular smooth muscle cell (SMC) proliferation, migration and extracellular matrix (ECM) synthesis are key events in the development of intimal hyperplasia, a pathophysiological response to acute or chronic sources of vascular damage that can lead to occlusive narrowing of the vessel lumen. Atherosclerosis, the primary cause of coronary artery disease, is characterised by chronic vascular inflammation and dyslipidemia, while revascularisation surgeries such as coronary stenting and bypass grafting represent acute forms of vascular injury. Gene knockouts of transforming growth factor-beta (TGFβ), its receptors and downstream signalling proteins have demonstrated the importance of this pleiotropic cytokine during vasculogenesis and in the maintenance of vascular homeostasis. Dysregulated TGFβ signalling is a hallmark of many vascular diseases, and has been associated with the induction of pathological vascular cell phenotypes, fibrosis and ECM remodelling. Here we present an overview of TGFβ signalling in SMCs, highlighting the ways in which this multifaceted cytokine regulates SMC behaviour and phenotype in cardiovascular diseases driven by intimal hyperplasia.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Low, Emma and Bradshaw, Dr Angela and Baker, Professor Andrew
Authors: Low, E. L., Baker, A. H., and Bradshaw, A. C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Cellular Signalling
Publisher:Elsevier
ISSN:0898-6568
ISSN (Online):1873-3913
Published Online:15 September 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Cellular Signalling 53:90-101
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
601813A novel approach to ameliorating vascular pathologies driven by Transforming Growth Factor-betaAngela BradshawThe Royal Society of Edinburgh (ROYSOCED)C33457RI CARDIOVASCULAR & MEDICAL SCIENCES
583362BHF Chair of Translational Cardiovascular SciencesAndrew BakerBritish Heart Foundation (BHF)SS/CH/11/2/28733RI CARDIOVASCULAR & MEDICAL SCIENCES
492454BHF 4 Year PhD ProgrammeAnna DominiczakBritish Heart Foundation (BHF)FS/12/66/30003RI CARDIOVASCULAR & MEDICAL SCIENCES