A novel biosensor based on Au@Ag core-shell nanoparticles for sensitive detection of methylamphetamine with surface enhanced Raman scattering

Mao, K., Zhou, Z., Han, S., Zhou, X., Hu, J., Li, X. and Yang, Z. (2018) A novel biosensor based on Au@Ag core-shell nanoparticles for sensitive detection of methylamphetamine with surface enhanced Raman scattering. Talanta, 190, pp. 263-268. (doi:10.1016/j.talanta.2018.07.071) (PMID:30172508)

[img] Text
169171.pdf - Accepted Version
Restricted to Repository staff only until 25 July 2019.

1MB

Abstract

We describe a novel biosensing strategy for sensitive detection of methylamphetamine (MAMP) based on surface enhanced Raman scattering (SERS) by the mediation of spacing between 4-mercaptobenzoic acid (4-MBA) labeled Au@Ag core-shell nanoparticles (Au@Ag). To achieve a favorable SERS substrate, Au@Ag shell-core nanoparticle was synthesized with seeds growth method and well characterized by SEM, TEM and UV-vis spectrometer. The uniform Au@Ag shows an excellent dispersion ability for SERS detection. Under the optimized conditions, the novel biosensor shows a good logarithm linear correlation with the concentration of MAMP ranging from 0.5 ppb to 40 ppb (R = 0.986), with a limit of detection at 0.16 ppb of MAMP (3σ). Furthermore, our biosensors hold an excellent selectivity, demonstrated by the negligible interference from the detection of other illicit drugs and metabolites. The concentrations determined with our biosensor from spiked MAMP in human urine sample fell within the same range with the results from mass spectrometry. This indicates that our sensor has a clear potential for the rapid detection of illicit drug in real samples.

Item Type:Articles
Additional Information:We gratefully acknowledge the support from the Natural Science Foundation of China (NSFC) (No. 41371442 and 41401566). ZY thanks UK NERC personal fellowship grant (NE/R013349/1).
Keywords:Aptamer, Au@Ag, methylamphetamine, SERS, illicit drug of abuse
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Yang, Dr Zhugen
Authors: Mao, K., Zhou, Z., Han, S., Zhou, X., Hu, J., Li, X., and Yang, Z.
College/School:College of Science and Engineering > School of Engineering > Infrastructure and Environment
Journal Name:Talanta
Publisher:Elsevier
ISSN:0039-9140
ISSN (Online):1873-3573
Published Online:25 July 2018
Copyright Holders:Copyright © 2018 Elsevier
First Published:First published in Talanta 190:263-268
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
3019130Lab-on-a-Paper for Point-of-Care Microbial Source TrackingZhugen YangNatural Environment Research Council (NERC)NE/R013349/1ENG - Biomedical Engineering