Resting-state gamma-band power alterations in schizophrenia reveal functional E/I-balance abnormalities across illness-stages

Grent-‘t-Jong, T. et al. (2018) Resting-state gamma-band power alterations in schizophrenia reveal functional E/I-balance abnormalities across illness-stages. eLife, 7, e37799. (doi:10.7554/eLife.37799) (PMID:30260771) (PMCID:PMC6160226)

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Abstract

We examined alterations in E/I-balance in schizophrenia (ScZ) through measurements of resting-state gamma-band activity in participants meeting clinical high-risk (CHR) criteria (n = 88), 21 first episode (FEP) patients and 34 chronic ScZ-patients. Furthermore, MRS-data were obtained in CHR-participants and matched controls. Magnetoencephalographic (MEG) resting-state activity was examined at source level and MEG-data were correlated with neuropsychological scores and clinical symptoms. CHR-participants were characterized by increased 64–90 Hz power. In contrast, FEP- and ScZ-patients showed aberrant spectral power at both low- and high gamma-band frequencies. MRS-data showed a shift in E/I-balance toward increased excitation in CHR-participants, which correlated with increased occipital gamma-band power. Finally, neuropsychological deficits and clinical symptoms in FEP and ScZ-patients were correlated with reduced gamma band-activity, while elevated psychotic symptoms in the CHR group showed the opposite relationship. The current study suggests that resting-state gamma-band power and altered Glx/GABA ratio indicate changes in E/I-balance parameters across illness stages in ScZ.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Uhlhaas, Professor Peter and Goense, Dr Jozien and Gross, Professor Joachim and Grent-'T-Jong, Dr Tineke and Gumley, Professor Andrew and Gajwani, Dr Ruchika
Creator Roles:
Grent-'T-Jong, T.Conceptualization, Software, Formal analysis, Methodology, Writing – original draft, Writing – review and editing
Gross, J.Formal analysis, Funding acquisition, Writing – original draft
Goense, J.Formal analysis, Writing – original draft
Gajwani, R.Project administration
Gumley, A. I.Funding acquisition
Uhlhaas, P. J.Conceptualization, Supervision, Funding acquisition, Methodology, Writing – original draft, Project administration, Writing – review and editing
Authors: Grent-‘t-Jong, T., Gross, J., Goense, J., Wibral, M., Gajwani, R., Gumley, A. I., Lawrie, S. M., Schwannauer, M., Schultze-Lutter, F., Navarro Schröder, T., Koethe, D., Leweke, M. F., Singer, W., and Uhlhaas, P. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:eLife
Publisher:eLife Sciences Publications
ISSN:2050-084X
ISSN (Online):2050-084X
Copyright Holders:Copyright © 2018 Grent-‘t-Jong et al.
First Published:First published in eLife 7: e37799
Publisher Policy:Reproduced under a Creative Commons License
Data DOI:10.5061/dryad.vn23kb7

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
640693Using Magnetoencephalography to Investigate Aberrant Neural Synchrony in Prodromal Schizophrenia: A Translational Biomarker ApproachPeter UhlhaasMedical Research Council (MRC)MR/L011689/1RI NEUROSCIENCE & PSYCHOLOGY

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