Stratified medical therapy using invasive coronary function testing in angina: CorMicA trial

Ford, T. J. et al. (2018) Stratified medical therapy using invasive coronary function testing in angina: CorMicA trial. Journal of the American College of Cardiology, 72(23 PtA), pp. 2841-2855. (doi: 10.1016/j.jacc.2018.09.006) (PMID:30266608)

Abstract

Background: Angina without obstructive epicardial coronary artery disease (CAD) is a common problem with distinct underlying causes. Objectives: The purpose of this study was to test the hypothesis that stratified medical therapy guided by an interventional diagnostic procedure (IDP) improves patient outcomes. Methods: The authors conducted a randomized, controlled, blinded clinical trial of stratified medical therapy versus standard care in patients with angina. Patients with angina undergoing invasive coronary angiography (standard care) were recruited. Patients without obstructive CAD were immediately randomized 1:1 to the intervention group (stratified medical therapy) or the control group (standard care, IDP sham procedure). Vasoreactivity testing was performed by infusing incremental concentrations of acetylcholine (ACh) followed by a bolus vasospasm provocation (≤100 μg). The primary endpoint was the mean difference in angina severity at 6 months (assessed by the Seattle Angina Questionnaire summary score). Results: A total of 391 patients were enrolled between November 25, 2016 and November 12, 2017. Coronary angiography revealed obstructive disease in 206 (53.7%). A total of 151 (39%) patients without angiographically obstructive CAD were randomized (n = 76 intervention group; n = 75 blinded control group). The intervention resulted in a mean improvement of 11.7 units in the Seattle Angina Questionnaire summary score at 6 months (95% confidence interval [CI]: 5.0 to 18.4; p = 0.001). In addition, the intervention led to improvements in the mean quality of life score (EQ5D index 0.10 units; 95% CI: 0.01 to 0.18; p = 0.024) and visual analogue score (14.5 units; 95% CI: 7.8 to 21.3; p < 0.001). There were no differences in major adverse cardiac events (MACE) at the 6-month follow-up (2.6% controls vs. 2.6% intervention; p = 1.00). Conclusions: Coronary angiography often fails to identify patients with vasospastic and/or microvascular angina. Stratified medical therapy, including an IDP with linked medical therapy, is routinely feasible and improves angina in patients with no obstructive CAD. (CORonary MICrovascular Angina [CorMicA]; NCT03193294)

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Berry, Professor Colin and McConnachie, Professor Alex and Stanley, Miss Bethany and Robertson, Dr Keith and Shaukat, Dr Aadil and Ford, Thomas and Collison, Dr Damien and McCartney, Dr Peter and Eteiba, Professor Hany and Oldroyd, Dr Keith and Corcoran, Dr David and Sidik, Ms Novalia and Touyz, Professor Rhian and Rush, Dr Christopher and Hood, Dr Stuart
• Authors: Ford, T. J., Stanley, B., Good, R., Rocchiccioli, P., McEntegart, M., Watkins, S., Eteiba, H., Shaukat, A., Lindsay, M., Robertson, K., Hood, S., McGeoch, R., McDade, R., Yii, E., Sidik, N., McCartney, P., Corcoran, D., Collison, D., Rush, C., McConnachie, A., Touyz, R., Oldroyd, K., and Berry, C.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre; College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Journal of the American College of Cardiology
• Publisher: Elsevier
• ISSN: 0735-1097
• ISSN (Online): 1558-3597
• Published Online: 25 September 2018