Altowati, M. A., Shepherd, S., McGrogan, P., Russell, R. K., Ahmed, S. F. and Wong, S. C. (2018) Effects of recombinant human growth hormone in children with Crohn's disease on the muscle-bone unit: a preliminary study. Hormone Research in Paediatrics, 90, pp. 128-131. (doi: 10.1159/000492398)
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Abstract
There is limited information on the impact of recombinant human growth hormone (rhGH) on the muscle-bone unit in children with Crohn's disease (CD). In this pilot study, we report on the effects of rhGH on bone formation, dual-energy X-ray absorptiometry (DXA) total body (TB) bone mineral density adjusted for height and lumbar spine (LS) bone mineral apparent density (BMAD), and body composition. Prospective study of 8 children with CD (6 male), aged 14.8 years (9.0-16.4), who received rhGH for 24 months. Serum procollagen type 1 N-terminal propeptide (P1NP) was measured at baseline and at 6 months. DXA was performed every 6 months. Six months of rhGH led to improvement in P1NP SDS adjusted for bone age from -3.6 (-7.9 to -0.9) to -2.4 (-3.7 to 0.4) (p = 0.01). At baseline, reduction in LS-BMAD and TB lean mass SDS was observed being -1.2 (-3.6 to 0.8) (p = 0.01 vs. zero) and -0.8 (-2.4 to 3.0) (p = 0.11 vs. zero), respectively. No significant changes were seen in DXA bone and muscle parameters over the 24 months. Twenty-four months of therapy with rhGH in CD did not lead to an improvement in DXA BMD and lean mass, despite improvement in P1NP and linear growth.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Russell, Dr Richard and Wong, Dr Jarod and Shepherd, Dr Sheila and ALTOWATI, Mabrouka and Ahmed, Professor Syed Faisal |
| Authors: | Altowati, M. A., Shepherd, S., McGrogan, P., Russell, R. K., Ahmed, S. F., and Wong, S. C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Hormone Research in Paediatrics |
| Publisher: | Karger Publishers |
| ISSN: | 1663-2818 |
| ISSN (Online): | 1663-2826 |
| Published Online: | 27 August 2018 |
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