Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena = Association between FTO (ns9939609) genotype and adiposity markers in Chilean adults

Petermann, F. et al. (2018) Asociación entre el polimorfismo rs9939609 del gen FTO y marcadores de adiposidad en población adulta chilena = Association between FTO (ns9939609) genotype and adiposity markers in Chilean adults. Revista Medica de Chile, 146(6), pp. 717-726. (doi: 10.4067/s0034-98872018000600717) (PMID:30148903)

[img]
Preview
Text
168686.pdf - Published Version
Available under License Creative Commons Attribution.

644kB

Abstract

Background: Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity. Aim: To investigate the association of FTO gene with adiposity markers in Chilean adults. Material and Methods: 409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were: body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio. Results: A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95% confidence intervals (CI): 0.45 to 3.87], p = 0.014), body mass index (0.61 kg.m-2 [95% CI: 0.12 to 1.20], p = 0.050) and fat mass (1.14% [95% CI: 0.39 to 1.89], p = 0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score. Conclusions: This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Celis, Dr Carlos and Petermann, Mrs Fanny
Authors: Petermann, F., Villagrán, M., Troncoso, C., Mardones, L., Leiva, A. M., Martínez, M. A., Garrido-Méndez, A., Poblete-Valderrama, F., Salas-Bravo, C., Ramírez-Vélez, R., Ulloa, N., Pérez-Bravo, F., and Celis-Morales, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Revista Medica de Chile
Publisher:Sociedad Medica de Santiago
ISSN:0717-6163
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Revista Medica de ChileRevista Medica de Chile 146(6): 717-726
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record