Lung cancer CT screening: psychological responses in the presence and absence of pulmonary nodules

Clark, M. E. et al. (2018) Lung cancer CT screening: psychological responses in the presence and absence of pulmonary nodules. Lung Cancer, 124, pp. 160-167. (doi:10.1016/j.lungcan.2018.08.001)

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Abstract

Objectives: To determine the psychological response (thoughts, perceptions and affect) to a diagnosis of pulmonary nodules following a novel antibody blood test and computed tomography (CT) scans within a UK population. Materials and methods: This study was nested within a randomised controlled trial of a blood test (Early CDT®-Lung test), followed by a chest x-ray and serial CT-scanning of those with a positive blood test for early detection of lung cancer (ECLS Study). Trial participants with a positive Early CDT®-Lung test were invited to participate (n = 338) and those agreeing completed questionnaires assessing psychological outcomes at 1, 3 and 6 months following trial recruitment. Responses of individuals with pulmonary nodules on their first CT scan were compared to those without (classified as normal CT) at 3 and 6 months follow-up using random effects regression models to account for multiple observations per participant, with loge transformation of data where modelling assumptions were not met. Results: There were no statistically significant differences between the nodule and normal CT groups in affect, lung cancer worry, health anxiety, illness perceptions, lung cancer risk perception or intrusive thoughts at 3 or 6 months post-recruitment. The nodule group had statistically significantly fewer avoidance symptoms compared to the normal CT group at 3 months (impact of events scale avoidance (IES-A) difference between means −1.99, 95%CI −4.18, 0.21) than at 6 months (IES-A difference between means 0.88, 95%CI −1.32, 3.08; p-value for change over time = 0.003) with similar findings using loge transformed data. Conclusion: A diagnosis of pulmonary nodules following an Early CDT®-Lung test and CT scan did not appear to result in adverse psychological responses compared to those with a normal CT scan.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mair, Professor Frances
Authors: Clark, M. E., Bedford, L. E., Young, B., Robertson, J. F.R., das Nair, R., Vedhara, K., Littleford, R., Sullivan, F. M., Mair, F. S., Schembri, S., Rauchhaus, P., and Kendrick, D.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > General Practice and Primary Care
Journal Name:Lung Cancer
Publisher:Elsevier
ISSN:0169-5002
ISSN (Online):1872-8332
Published Online:03 August 2018

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