The association of acylcarnitines and amino acids with age in Dutch and South-Asian Surinamese living in Amsterdam.

Muilwijk, M., Vaz, F. M., Celis-Morales, C. , Peters, R. J.G. and van Valkengoed, I. G.M. (2018) The association of acylcarnitines and amino acids with age in Dutch and South-Asian Surinamese living in Amsterdam. Journal of Clinical Endocrinology and Metabolism, 103(10), pp. 3783-3791. (doi:10.1210/jc.2018-00809) (PMID:30113646)

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Abstract

Type 2 diabetes and cardiovascular disease occur more frequently, and at a younger age in South-Asians than Europeans. This may be related to differences in regulation of the fatty acid metabolism during aging. We compared age-related acylcarnitine and amino acid concentrations. We measured types of acylcarnitine and amino acid concentrations in plasma (by tandem-MS) in a random subsample of 350 Dutch and 350 South-Asian Surinamese origin participants of the HELIUS study (Amsterdam, The Netherlands). We derived principal components (PCs) from the metabolites. Linear regression was used to assess differences in PCs and individual metabolite concentrations, and their age-trends between the groups by sex. We adjusted for BMI and intake of fat and total energy. Mean age was 44.8 (SD 13.3) years. Many metabolite concentrations were higher among South-Asian Surinamese participants compared to Dutch participants; amino acids in women, and both acylcarnitines and amino acids in men. Metabolite levels increased similarly with age in both ethnic groups. Results remained similar after adjustment. Ethnic differences in metabolite concentrations suggest that fatty acid and amino acid metabolism are more dysregulated among South-Asian Surinamese compared to Dutch from a young age. During adulthood metabolites increase similarly in both ethnic groups.

Item Type:Articles
Additional Information:The HELIUS study is conducted by the Academic Medical Center Amsterdam and the Public Health Service of Amsterdam. Both organizations provided core support for HELIUS. The HELIUS study is also funded by the Dutch Heart Foundation, the Netherlands Organization for Health Research and Development (ZonMw), the European Union (FP-7), and the European Fund for the Integration of non-European Union immigrants (EIF). This work was additionally supported by a grant from the Health Programme 2014- 2020 from the European Union (Grant 664609 HP-PJ-2014).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Celis, Dr Carlos
Authors: Muilwijk, M., Vaz, F. M., Celis-Morales, C., Peters, R. J.G., and van Valkengoed, I. G.M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Journal of Clinical Endocrinology and Metabolism
Publisher:Oxford University Press
ISSN:0021-972X
ISSN (Online):1945-7197
Copyright Holders:Copyright © 2018 The Endocrine Society
First Published:First published in Journal of Clinical Endocrinology and Metabolism 103(10):3783-3791
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
704241InPreSDJason GillEuropean Commission (EC)664609RI CARDIOVASCULAR & MEDICAL SCIENCES