The comparative efficacy of antiseptics against Candida auris biofilms

Kean, R., McKloud, E., Townsend, E. M., Sherry, L., Delaney, C., Jones, B. L., Williams, C. and Ramage, G. (2018) The comparative efficacy of antiseptics against Candida auris biofilms. International Journal of Antimicrobial Agents, 52(5), pp. 673-677. (doi:10.1016/j.ijantimicag.2018.05.007) (PMID:29775686)

Kean, R., McKloud, E., Townsend, E. M., Sherry, L., Delaney, C., Jones, B. L., Williams, C. and Ramage, G. (2018) The comparative efficacy of antiseptics against Candida auris biofilms. International Journal of Antimicrobial Agents, 52(5), pp. 673-677. (doi:10.1016/j.ijantimicag.2018.05.007) (PMID:29775686)

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Abstract

Candida auris has emerged as a significant clinical entity due to its ability to cause outbreaks within the healthcare setting. A key feature of its nosocomial lifestyle is its ability to transfer between patients, yet little is known about the mechanisms behind this. A panel of C. auris clinical isolates was screened for their planktonic and sessile susceptibilities to skin disinfection challenge using povidone iodine, chlorhexidine and hydrogen peroxide. C. auris biofilms displayed increased tolerance to these strategies compared to planktonic cells. Additionally, analysis using a complex biofilm model demonstrated reduced susceptibility against clinically relevant concentrations of chlorhexidine and hydrogen peroxide, with complete eradication achieved only using povidone iodine. Principal component analysis (PCA) also revealed distinct clustering of C. auris biofilms in comparison to C. albicans and C. glabrata biofilms, and directionality with respect to different treatments. These findings indicate differential responses of different Candida species with respect to antiseptic challenge against biofilms, with C. auris appearing to be more resilient as a complex community.

Item Type:Articles
Additional Information:We would like to thank the European Society for Clinical Microbiology and Infectious Disease for financial support for LS.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kean, Mr Ryan and Williams, Dr Craig and Jones, Dr Brian and Sherry, Dr Leighann and Ramage, Professor Gordon and Townsend, Miss Eleanor and Delaney, Christopher
Authors: Kean, R., McKloud, E., Townsend, E. M., Sherry, L., Delaney, C., Jones, B. L., Williams, C., and Ramage, G.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:International Journal of Antimicrobial Agents
Publisher:Elsevier
ISSN:0924-8579
ISSN (Online):1872-7913
Published Online:15 May 2018
Copyright Holders:Copyright © 2018 Elsevier B.V. and International Society of Chemotherapy
First Published:First published in International Journal of Antimicrobial Agents 52(5): 673-677
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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